Acerca de este Curso
5,170 vistas recientes

100 % en línea

Comienza de inmediato y aprende a tu propio ritmo.

Fechas límite flexibles

Restablece las fechas límite en función de tus horarios.

Nivel principiante

Aprox. 11 horas para completar

Sugerido: 12-18 hours of videos and labs...

Inglés (English)

Subtítulos: Inglés (English)

100 % en línea

Comienza de inmediato y aprende a tu propio ritmo.

Fechas límite flexibles

Restablece las fechas límite en función de tus horarios.

Nivel principiante

Aprox. 11 horas para completar

Sugerido: 12-18 hours of videos and labs...

Inglés (English)

Subtítulos: Inglés (English)

Programa - Qué aprenderás en este curso

Semana
1
3 horas para completar

Protein Motifs

In this module we'll be exploring conserved regions within protein families. Such regions can help us understand the biology of a sequence, in that they are likely important for biological function, and also be used to help ascribe function to sequences where we can't identify any homologs in the databases. There are various ways of describing the conserved regions from simple regular expressions to profiles to profile hidden Markov models (HMMs).

...
4 videos (Total 34 minutos), 4 readings, 1 quiz
4 videos
Lecture21m
Lab Discussion9m
Summary1m
4 lecturas
Acknowledgements10m
Course Logistics10m
Lecture Materials10m
Lab 1 -- Protein Domain, Motif and Profile Analysis1h 30m
1 ejercicio de práctica
Lab 1 Quiz6m
Semana
2
2 horas para completar

Protein-Protein Interactions

In this module we'll be exploring protein-protein interactions (PPIs). Protein-protein interactions are important as proteins don't act in isolation, and often an examination of the interaction partners (determined in an unbiased, perhaps high throughput way) of a given protein can tell us a lot about its biology. We'll talk about some different methods used to determine PPIs and go over their strengths and weaknesses. In the lab we'll use 3 different tools and two different databases to examine interaction partners of BRCA2, a protein that we examined in last module's lab. Finally, we'll touch on a "foundational" concept, Gene Ontology (GO) term enrichment analysis, to help us understand in an overview way the proteins interacting with our example.

...
4 videos (Total 37 minutos), 2 readings, 1 quiz
4 videos
Lecture23m
Lab Discussion11m
Summary1m
2 lecturas
Lecture Materials10m
Lab 2 -- Protein-Protein Interactions1h 30m
1 ejercicio de práctica
Lab 2 Quiz6m
Semana
3
2 horas para completar

Protein Structure

The determination of a protein's tertiary structure in three dimensions can tell us a lot about the biology of that protein. In this module's mini-lecture, we'll talk about some different methods used to determine a protein's tertiary structure and cover the main database for protein structure data, the PDB. In the lab we'll explore the PDB and an online tool for searching for structural (as opposed to sequence) similarity, VAST. We'll then use a nice piece of stand-alone software, PyMOL, to explore several protein structures in more detail.

...
4 videos (Total 32 minutos), 2 readings, 1 quiz
4 videos
Lecture13m
Lab Discussion16m
Summary1m
2 lecturas
Lecture Materials10m
Lab 3 -- Structural Bioinformatics1h 30m
1 ejercicio de práctica
Lab 3 Quiz6m
Semana
4
10 minutos para completar

Review: Protein Motifs, Protein-Protein Interactions, and Protein Structure

...
1 quiz
1 ejercicio de práctica
Quiz: Protein Motifs, Protein-Protein Interactions, and Protein Structure10m
4.7
39 revisionesChevron Right

20%

comenzó una nueva carrera después de completar estos cursos

25%

consiguió un beneficio tangible en su carrera profesional gracias a este curso

11%

consiguió un aumento de sueldo o ascenso

Principales revisiones sobre Bioinformatic Methods II

por RGApr 6th 2017

Gives the student real world exposure to the tools to study proteins gene regulation, etc. Instructor is involved and friendly. Highly recommended for someone who is interested in contemporary

por NMJan 9th 2018

Hi Nicholas, Thank you so much for giving a lot of information. Bioinformatic Methods II was little difficult but understood after repeating the lad discussions. Thanks a lot.

Instructor

Avatar

Nicholas James Provart

Professor
Cell & Systems Biology

Acerca de Universidad de Toronto

Established in 1827, the University of Toronto is one of the world’s leading universities, renowned for its excellence in teaching, research, innovation and entrepreneurship, as well as its impact on economic prosperity and social well-being around the globe. ...

Preguntas Frecuentes

  • Una vez que te inscribes para obtener un Certificado, tendrás acceso a todos los videos, cuestionarios y tareas de programación (si corresponde). Las tareas calificadas por compañeros solo pueden enviarse y revisarse una vez que haya comenzado tu sesión. Si eliges explorar el curso sin comprarlo, es posible que no puedas acceder a determinadas tareas.

  • Cuando compras un Certificado, obtienes acceso a todos los materiales del curso, incluidas las tareas calificadas. Una vez que completes el curso, se añadirá tu Certificado electrónico a la página Logros. Desde allí, puedes imprimir tu Certificado o añadirlo a tu perfil de LinkedIn. Si solo quieres leer y visualizar el contenido del curso, puedes participar del curso como oyente sin costo.

¿Tienes más preguntas? Visita el Centro de Ayuda al Alumno.