Acerca de este Curso
4.7
41 calificaciones
6 revisiones
100 % en línea

100 % en línea

Comienza de inmediato y aprende a tu propio ritmo.
Fechas límite flexibles

Fechas límite flexibles

Restablece las fechas límite en función de tus horarios.
Nivel intermedio

Nivel intermedio

Horas para completar

Aprox. 19 horas para completar

Sugerido: 6 weeks of study, 3-5 hours a week...
Idiomas disponibles

Inglés (English)

Subtítulos: Inglés (English)
100 % en línea

100 % en línea

Comienza de inmediato y aprende a tu propio ritmo.
Fechas límite flexibles

Fechas límite flexibles

Restablece las fechas límite en función de tus horarios.
Nivel intermedio

Nivel intermedio

Horas para completar

Aprox. 19 horas para completar

Sugerido: 6 weeks of study, 3-5 hours a week...
Idiomas disponibles

Inglés (English)

Subtítulos: Inglés (English)

Programa - Qué aprenderás en este curso

Semana
1
Horas para completar
3 horas para completar

Introduction. Human genome

This week you will learn about human genome organisation. This week is very important as all this knowledge will form a basis for all of the subsequent weeks of the course. Michel Georges will tell you about the structural organisation of the human genome, the mechanisms contributing to the genome variability, the main types of genetic variation (SNPs, CNVs, aneuploidy, etc.), and differences between alleles and genotypes. You will also learn the techniques used to detect different types of variations in human genome and you will find out how we can follow the inheritance of genetic material through generations. ...
Reading
7 videos (Total 54 minutos), 9 readings, 9 quizzes
Video7 videos
Course Introduction1m
Anatomy of the Human Genome13m
Identifying Functionally Important Elements in the Human Reference Genome12m
Genetic Polymorphism11m
Interrogating Genetic Variation10m
Week 1 Conclusion2m
Reading9 lecturas
Meet your Educators and Fellow Learners10m
Course Navigation10m
Typos in videos10m
Recommended Pre-reading10m
The Human Genome Project30m
Recommended Pre-reading10m
Recommended Pre-reading10m
Recommended Pre-reading10m
Glossary Week 110m
Quiz9 ejercicios de práctica
Pre-lecture Questions6m
Practice Quiz2m
Pre-lecture Questions4m
Practice Quiz2m
Pre-lecture Questions4m
Practice Quiz4m
Pre-lecture Questions6m
Practice Quiz2m
Introduction. Human Genome8m
Semana
2
Horas para completar
4 horas para completar

Populational genetics

During this week, Yurii Aulchenko will teach you the basics of population and quantitative genetics. Population genetics is a branch of genetics that deals with genetic variation among individuals in a population. "Nothing in Biology Makes Sense Except in the Light of Evolution" is a quotation from a 1973 essay by the evolutionary biologist Theodosius Dobzhansky. The fundamental importance of population genetics lies in the insights it provides into the mechanisms of evolution, thus allowing geneticists to better understand the drivers behind the organization and functioning of human genomes. You will learn about such phenomena as population structure, selection and genetic drift. You will also learn about quantitative genetics, which studies how the genes and environment control variations in complex phenotypes....
Reading
7 videos (Total 59 minutos), 13 readings, 13 quizzes
Video7 videos
Hardy-Weinberg Equilibrium8m
Linkage Disequilibrium8m
Natural Selection11m
Genetic Drift9m
Genetic Structure12m
Week 2 Conclusion2m
Reading13 lecturas
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Glossary Week 210m
Quiz13 ejercicios de práctica
Pre-lecture Questions4m
Practice Quiz4m
Pre-lecture Questions6m
Practice Quiz4m
Pre-lecture Questions4m
Practice Quiz4m
Pre-lecture Questions4m
Practice Quiz2m
Pre-lecture Questions4m
Practice Quiz4m
Pre-lecture Questions2m
Practice Quiz4m
Populational Genetics14m
Semana
3
Horas para completar
3 horas para completar

Mendelian disorders

Mendelian or monogenic disorders are the kind of genetic disorders in humans that arise from a mutation in a single gene. These disorders run in families and can be autosomal or sex-linked depending whether the affected gene is located on autosomes or sex chromosomes, and they can also be dominant or recessive depending if one or two alleles are necessary to develop the disorder. The name “Mendelian” is used because these diseases follow simple monogenic patterns of inheritance, similar to these first studied by Gregor Mendel in pea plants. There are an estimated 8000 rare Mendelian diseases. Although each of them are very rare, collectively they affect millions of individuals world-wide. How can we find the variants and genes that are responsible for the development of these diseases? You will learn about “linkage analysis” – a technique that has been previously used for this purpose. You will also learn about Next-generation sequencing (NGS) technologies that have revolutionized the studies of Mendelian diseases in recent years. ...
Reading
6 videos (Total 51 minutos), 10 readings, 11 quizzes
Video6 videos
Linkage Analysis. Family Studies11m
NGS for Studying Monogenic Disorders — Part I7m
NGS for Studying Monogenic Disorders — Part II10m
NGS for Studying Monogenic Disorders — Part III11m
Week 3 Conclusion1m
Reading10 lecturas
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Mendelian disorders: discussion10m
Glossary Week 310m
Quiz11 ejercicios de práctica
Pre-lecture Questions2m
Practice Quiz2m
Pre-lecture Questions2m
Practice Quiz2m
Pre-lecture Questions2m
Practice Quiz2m
Pre-lecture Questions4m
Practice Quiz2m
Pre-lecture Questions2m
Practice Quiz2m
Mendelian Disorders10m
Semana
4
Horas para completar
6 horas para completar

Complex disorders

In contrast to Mendelian disorders that are controlled by a mutation in one gene, the multifactorial disorders are more complex, thus the name. These disorders are affected by an interplay of many genetic and environmental factors and also by a chance. Most of the human disorders, including prevalent types of diabetes, cardiovascular diseases, different cancers, are of such type. Although these disorders often cluster in families, they do not segregate in ways that are consistent with simple Mendelian inheritance. The methods used to find variants responsible for Mendelian disorders are not applicable for complex ones. Genome-wide association studies, or “GWAS” is a current method of choice to pinpoint the genetic variation predisposing to complex disorders. Yurii Aulchenko together with Lennart Karssen will tell you about this method and discuss its advantages and limitations. ...
Reading
10 videos (Total 88 minutos), 18 readings, 19 quizzes
Video10 videos
Introduction to Genome-Wide Association Studies. Historical Overview12m
GWAS Nowadays. Imputations10m
4.4. Analysis of Directly Genotyped and Imputed data. Significance of GWAS11m
4.5. Population Stratification and its Consequences10m
4.6. Analysis of Genetically Structured Populations9m
4.7. Meta-analysis of GWAS Results: Theory and Background6m
4.8. Quality Control of GWAS Array Data10m
4.9. Meta-analysis of GWAS Results: Practical Details8m
Week 4 Conclusion2m
Reading18 lecturas
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Recommended Pre-reading10m
Additional Materials10m
Additional Materials10m
Glossary Week 410m
Quiz19 ejercicios de práctica
Pre-lecture Questions4m
Practice Quiz4m
Pre-lecture Questions2m
Practice Quiz6m
Pre-lecture Questions2m
Practice Quiz2m
Pre-lecture Questions4m
Post-lecture Questions4m
Pre-lecture Questions2m
Post-lecture Questions4m
Pre-lecture Questions4m
Post-lecture Questions6m
Pre-lecture Questions2m
Post-lecture Questions4m
Pre-lecture Questions2m
Post-lecture Questions2m
Pre-lecture Questions2m
Quiz4m
Complex disorders26m
4.7
6 revisionesChevron Right
Promoción de la carrera

50%

consiguió un aumento de sueldo o ascenso

Principales revisiones

por FLSep 27th 2018

Highly recommended!\n\nAn interesting, up-to-date course with eye-catching and well designed videos.

por JQDec 30th 2017

Fun and interesting course. Great review of material I had forgotten, sadly.

Instructores

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Marianna Bevova

PhD, Director of GIGA Doctoral School
University of Liège (GIGA)
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Michel Georges

PhD, Professor, GIGA Research Director
University of Liège
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Gert Matthijs

PhD, Professor
Center for Human Genetics, University of Leuven
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Lennart Karssen

PhD, Owner and Chief Computational Scientist
PolyOmica
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Natalia Aulchenko

M.Sc., Project manager
Theoretical and Applied Functional Genomics Laboratory
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Yakov Tsepilov

PhD, Senior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Sodbo Sharapov

M.Sc, Junior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Alexander Tashkeev

Skolkovo Institute of Science and Technology (Skoltech), Junior Researcher
Laboratory of Computational and Structural Transcriptomics
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Yurii Aulchenko

PhD, Professor, Head of Theoretical and Applied Functional Genomics Laboratory
Theoretical and Applied Functional Genomics Laboratory

Acerca de Novosibirsk State University

Novosibirsk State University (NSU) is a research university located in Novosibirsk Akademgorodok, the world-famous scientific center in Siberia. 80% of NSU teachers are active researchers affiliated with the Russian Academy of Sciences; therefore education is closely linked to world-class science: our students get first-hand knowledge about scientific discoveries before they are published. Nearly 6000 students (including international students from 37 countries) are enrolled at undergraduate and graduate programs offered by 13 departments. The leading areas of NSU expertise are natural sciences, life sciences, physics, math, IT, and more....

Preguntas Frecuentes

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