While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics.
Gratis
Acceso gratuito a todas las conferencias, lecturas y tareas
ofrecido por
Epigenetic Control of Gene Expression
Universidad de MelbourneAcerca de este Curso
25,037 vistas recientes
Resultados profesionales del estudiante
33%
comenzó una nueva carrera después de completar estos cursos
38%
consiguió un beneficio tangible en su carrera profesional gracias a este curso
11%
consiguió un aumento de sueldo o ascenso
Certificado para compartir
Obtén un certificado al finalizar
100 % en línea
Comienza de inmediato y aprende a tu propio ritmo.
Fechas límite flexibles
Restablece las fechas límite en función de tus horarios.
Aprox. 18 horas para completar
Inglés (English)
Subtítulos: Inglés (English), Español (Spanish)
Habilidades que obtendrás
CancerMolecular BiologyCancer EpigeneticsDna Methylation
Resultados profesionales del estudiante
33%
comenzó una nueva carrera después de completar estos cursos
38%
consiguió un beneficio tangible en su carrera profesional gracias a este curso
11%
consiguió un aumento de sueldo o ascenso
Certificado para compartir
Obtén un certificado al finalizar
100 % en línea
Comienza de inmediato y aprende a tu propio ritmo.
Fechas límite flexibles
Restablece las fechas límite en función de tus horarios.
Aprox. 18 horas para completar
Inglés (English)
Subtítulos: Inglés (English), Español (Spanish)
ofrecido por
Universidad de Melbourne
The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University.
Programa - Qué aprenderás en este curso
2 horas para completar
Week 1 - Introduction to Epigenetic Control
An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability.
2 horas para completar
7 videos (Total 65 minutos), 5 lecturas, 1 cuestionario
7 videos
1.1 Introduction to the concepts of epigenetic control10m
1.2 Mitotic heritability of epigenetic marks10m
1.3 Chromatin and the nucleosome6m
1.4 Chromatin compaction - heterochromatin versus euchromatin9m
1.5 DNA methylation at CpG islands11m
1.6 DNA methylation at intergenic regions and repetitive elements15m
5 lecturas
Course syllabus10m
Teaching team10m
Start of course survey10m
Assessment and grading policy10m
Week 1 and 2 resources10m
1 ejercicio de práctica
Week 1 quiz - contributes 8% towards your final grade20m
2 horas para completar
Week 2 - Epigenetic Modifications and Organisation of the Nucleus
We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course.
2 horas para completar
9 videos (Total 90 minutos), 1 lectura, 1 cuestionario
9 videos
2.2 Histone acetylation and histone methylation12m
2.3 Chromatin remodelling12m
2.4 Histone variants8m
2.5 Noncoding RNAs - microRNAs6m
2.6 Noncoding RNAs - piRNAs9m
2.7 Noncoding RNAs - long noncoding RNAs introduction10m
2.8 Long noncoding RNAs Xist and HOTAIR7m
2.9 3D organisation of the nucleus and summary of epigenetic marks17m
1 lectura
Week 1 and 2 resources10m
1 ejercicio de práctica
Week 2 quiz - contributes 8% towards your final grade20m
3 horas para completar
Week 3 - Dosage Compensation
X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms.
3 horas para completar
12 videos (Total 113 minutos), 1 lectura, 1 cuestionario
12 videos
3.2 Timing of random and imprinted X chromosome inactivation8m
3.3 Stages of X inactivation - counting and control of Xist expression13m
3.4 Control of Xist expression by pluripotency factors6m
3.5 Stages of X inactivation - choice of which X to inactivate9m
3.6 Stages of X inactivation - initiation and spreading of silencing11m
3.7 Stages of X inactivation - establishment of silencing6m
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18m
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18m
3.10 X chromosome inactivation summary10m
3.11 Dosage compensation in flies and worms, compared with mammals8m
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10m
1 lectura
Week 3 resources (including required readings)10m
1 ejercicio de práctica
Week 3 quiz - contributes 12% towards your final grade30m
2 horas para completar
Week 4 - Genomic Imprinting and Epigenetic Reprogramming
We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth.
2 horas para completar
6 videos (Total 68 minutos), 1 lectura, 1 cuestionario
6 videos
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11m
4.3 Location of imprinted genes in the genome and bisulfite sequencing10m
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17m
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13m
4.6 Summary of epigenetic reprogramming and imprinting6m
1 lectura
Week 4 resources (including required reading)10m
1 ejercicio de práctica
Week 4 quiz - contributes 12% towards your final grade30m
Revisiones
Principales revisiones sobre EPIGENETIC CONTROL OF GENE EXPRESSION
por MM1 de oct. de 2018
This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.
por GK19 de may. de 2020
This course was new to me. All the concepts were explained in a very simplified manner. I am very happy to have done this course and find it a very interesting field to take upm in my future career.
por DS24 de ago. de 2018
This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!
por HD24 de nov. de 2019
Update the reading for the final assignment. It is too old and updating it would be an easy fix. I am not going to finish the certificate as the final paper is 7 years ago. Go Boomer. Sad
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