This course covers approaches for modelling treatment of infectious disease, as well as for modelling vaccination. Building on the SIR model, you will learn how to incorporate additional compartments to represent the effects of interventions, such the effect of vaccination in reducing susceptibility. You will learn about ‘leaky’ vaccines and how to model them, as well as different types of vaccine and treatment effects. It is important to consider basic relationships between models and data, so, using the basic SIR model you have developed in course 1, you will calibrate this model to epidemic data. Performing such a calibration by hand will help you gain an understanding of how model parameters can be adjusted in order to capture real-world data. Lastly in this course, you will learn about two simple approaches to computer-based model calibration - the least-squares approach and the maximum-likelihood approach; you will perform model calibrations under each of these approaches in R.
Este curso forma parte de Programa Especializado - Infectious Disease Modelling
ofrecido por
Programa Especializado - Infectious Disease ModellingImperial College LondonAcerca de este Curso
Qué aprenderás
Identify the relationship between models and real-world epidemiological data
Incorporate treatment or vaccination into an SIR model, accounting for imperfect efficacy, and for different mechanisms of action
Perform simple calibrations of an SIR model against time-series data, selecting parameters to maximise the fit of the model to the data
Recognise two simple approaches to computer-based model calibration and perform model calibrations under each of these approaches in R.
Habilidades que obtendrás
ofrecido por
Imperial College London
Imperial College London is a world top ten university with an international reputation for excellence in science, engineering, medicine and business. located in the heart of London. Imperial is a multidisciplinary space for education, research, translation and commercialisation, harnessing science and innovation to tackle global challenges.
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Programa - Qué aprenderás en este curso
Modelling Interventions
Once you have captured the basic dynamics of transmission using simple mathematical models, it is possible to use these models to simulate the impact of different interventions. You will study approaches for modelling treatment of infectious disease, as well as for modelling vaccination. Building on the SIR model, you will learn how to incorporate additional compartments to represent the effects of interventions (for example, the effect of vaccination in reducing susceptibility). You will learn about ‘leaky’ vaccines and how to model them, as well as different types of vaccine and treatment effects.
Confronting Models with Data - Part A
All models answering public health questions first need to be matched, or ‘calibrated’, against real-world data to ensure that model-simulated dynamics are consistent with what is observed. In this module, you will consider basic relationships between models and data. Using the basic SIR model that you've developed so far, you will calibrate this model to epidemic data. Through performing this calibration by hand, you'll gain an understanding of how model parameters can be adjusted so as to order to capture real-world data.
Confronting Models with Data - Part B
In practice model calibration for compartmental models is rarely done by hand. Rather, we construct a function that summarises the goodness-of-fit between the model and the data and then use available computer algorithms to maximise this goodness-of-fit. In these next two modules, you will learn about two simple approaches to computer-based model calibration: the least-squares approach and the maximum-likelihood approach. You will perform model calibrations under each of these approaches in R.
Confronting models with data – Part C
Please note - learning outcomes are the same across both this and the last module. In practice, model calibration for compartmental models is rarely done by hand. Rather, we construct a function that summarises the goodness-of-fit between the model and the data and then use available computer algorithms to maximise this goodness-of-fit. In these two modules, you'll learn about two simple approaches to computer-based model calibration: the least-squares approach, and the maximum-likelihood approach. You will perform model calibrations under each of these approaches in R.
Reseñas
Principales reseñas sobre INTERVENTIONS AND CALIBRATION
Such a great learning experience. The course provided me with a comprehensive overview of the topics under concern. My gratitude to the instructors for creating such a valuable course.
A great learning experience, have to struggle a lot for the quiz, But in the end it helps to get better understanding of the concept and practice.
Excellent course videos, content, assignment quiz. Received very good support from instructor and other members/ learners on discussion forum.
Excellent course led from first course right into this course perfectly. Level is perfect assignments perfect. Already told 5 people about it.
Acerca de Programa especializado: Infectious Disease Modelling
Mathematical modelling is increasingly being used to support public health decision-making in the control of infectious diseases. This specialisation aims to introduce some fundamental concepts of mathematical modelling with all modelling conducted in the programming language R - a widely used application today.
Preguntas Frecuentes
¿Cuándo podré acceder a las lecciones y tareas?
El acceso a las clases y las asignaciones depende del tipo de inscripción que tengas. Si tomas un curso en modo de oyente, verás la mayoría de los materiales del curso en forma gratuita. Para acceder a asignaciones calificadas y obtener un certificado, deberás comprar la experiencia de Certificado, ya sea durante o después de participar como oyente. Si no ves la opción de oyente:
- es posible que el curso no ofrezca la opción de participar como oyente. En cambio, puedes intentar con una Prueba gratis o postularte para recibir ayuda económica.
- Es posible que el curso ofrezca la opción 'Curso completo, sin certificado'. Esta opción te permite ver todos los materiales del curso, enviar las evaluaciones requeridas y obtener una calificación final. También significa que no podrás comprar una experiencia de Certificado.
¿Qué recibiré si me suscribo a este Programa especializado?
Cuando te inscribes en un curso, obtienes acceso a todos los cursos que forman parte del Programa especializado y te darán un Certificado cuando completes el trabajo. Se añadirá tu Certificado electrónico a la página Logros. Desde allí, puedes imprimir tu Certificado o añadirlo a tu perfil de LinkedIn. Si solo quieres leer y visualizar el contenido del curso, puedes auditar el curso sin costo.
Is financial aid available?
Sí, Coursera ofrece ayuda económica a los estudiantes que no pueden pagar la tarifa. Solicítala haciendo clic en el enlace de Ayuda económica que está debajo del botón “Inscribirse” a la izquierda. Se te pedirá que completes una solicitud. Recibirás una notificación en caso de que se apruebe. Deberás completar este paso para cada uno de los cursos que forman parte del Programa especializado, incluido el proyecto final. Obtén más información.
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