Sleep: Neurobiology, Medicine, and Society
ofrecido por
Sleep: Neurobiology, Medicine, and Society
University of Michigan
Acerca de este Curso
4.8
44 calificaciones
The objective of this course is to give students the most up-to-date information on the biological, personal, and societal relevance of sleep. Personal relevance is emphasized by the fact that the single best predictor of daytime performance is the quality of the previous night's sleep. The brain actively generates sleep, and the first section of the course is an overview of the neurobiological basis of sleep control. The course provides cellular-level understanding of how sleep deprivation, jet lag, and substances such as alcohol, ,caffeine, and nicotine alter sleep and wakefulness. The second section of the course covers sleep-dependent changes in physiology and sleep disorders medicine. Particular emphasis will be placed on disorders of excessive sleepiness, insomnia, and sleep-dependent changes in autonomic control. Chronic sleep deprivation impairs immune function and may promote obesity. Deaths due to all causes are most frequent between 4:00 and 6:00 a.m., and this second section of the class highlights the relevance of sleep for preventive medicine. The societal relevance of sleep will be considered in the final section of the class. In an increasingly complex and technologically oriented society, operator-error by one individual can have a disastrous negative impact on public health and safety. Fatigue-related performance decrements are known to have contributed as causal factors to nuclear power plant failures, transportation disasters, and medical errors.
Programa - Qué aprenderás en este curso
Week
1Unit 01 - Neurobiology Section: Course Introduction & Neurobiology of Sleep and Wakefulness (Part One) - (Standard Track & Honors Track)
This unit begins with a Course Overview video from Ralph Lydic, Ph.D., followed by the first portion of the Neurobiology of Sleep and Wakefulness lecture, delivered by Helen Baghdoyan, Ph.D. PLEASE NOTE: Only the Course Overview video, and the Getting Started and Syllabus readings are required for students who have chosen to engage in the Standard Track portion of the course content. Standard track students may also bypass all content in units 2, 3, and 4, and instead move directly to unit 5 after viewing the Course Overview video.
6 videos (Total: 93 min), 4 readings, 1 quiz
6 videos
02.01 - Learning Points14m
02.02 - Defining Behavioral States8m
02.03 - Historical Overview: Brainstem & Forebrain17m
02.04 - Wake & REM: Monoamines17m
02.05 - Wake & REM: Acetylcholine17m
4 lecturas
Getting Started10m
Syllabus10m
Help Us Learn More About You!10m
Lesson 2 Orientation10m
1 ejercicio de práctica
Did you Complete Lesson 2?2m
Week
2Unit 02 - Neurobiology Section: Neurobiology of Sleep and Wakefulness (Part Two) - (Honors Track)
Unit 2 continues the lecture from Helen Baghdoyan, Ph.D. on the Neurobiology of Sleep and Wakefulness. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
5 videos (Total: 73 min), 2 quizzes
5 videos
02.07: Wake & REM: Orexin17m
02.08: NREM: GABA14m
02.09: NREM: Adenosine 11m
02:10: Summary12m
2 ejercicios de práctica
Did you complete Lesson 03?2m
Unit 02 Honors Track Quiz - Neurobiology of Sleep and Wakefulness30m
Week
3Unit 03 - Neurobiology: Mathematical Modeling of Sleep-Wake Regulation - (Honors Track)
Unit 3 continues the Neurobiology section of the content with a lecture from Victoria Booth, Ph.D. on the Mathematical Modeling of Sleep-Wake Regulation. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
10 videos (Total: 67 min), 1 reading, 2 quizzes
10 videos
03.02 - Two Process Model 5m
03.03 - Sleep-Wake Flip-Flop Model5m
03.04 - Reciprocal Interaction Model 12m
03.05 - REM Sleep Flip-Flop Model4m
03.06 - Features for an Ideal Model of Sleep-Wake Regulation7m
03.07 - Introduction to Mechanistic Models of Sleep-Wake Regulation 3m
03.08 - Diniz Benh & Booth Model - Part I9m
03.09 - Diniz Benh & Booth Model - Part II 14m
03.10 - Conclusion 1m
1 lectura
Unit 03 Orientation10m
2 ejercicios de práctica
Did you Complete Lesson 5?2m
Unit 03 Quiz - Mathematical Modeling of Sleep-Wake Regulation10m
Week
4Unit 04 - Neurobiology: Molecular Biology and Genetics of Sleep - (Honors Track)
Unit 4 closes out the Neurobiology section with a lecture from Chiara Cirelli, Ph.D. on Molecular Biology and the Genetics of Sleep. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
6 videos (Total: 52 min), 2 quizzes
6 videos
04.02 - Wake Genes that are Associated with Energy Metabolism 7m
04.03 - Synaptic Plasticity is Genetically Modulated 7m
04.04 - Brain Glial Cells Influence States of Sleep and Wakefulness 9m
04.05 - Genetic Modulation of Human Sleep Phenotypes 8m
04.06 - Conclusion 11m
2 ejercicios de práctica
Did you complete Lesson 7?2m
Unit 04 Quiz - Molecular Biology and Genetics of Sleep10m
4.8
Principales revisiones
por JQ•Jan 3rd 2018
Excellent course! A great review on stuff I should have remembered but of course have forgotten as I've aged. My thanks to those organizing and teaching the course! Dr Quincy
por DF•Feb 19th 2018
I thoroughly enjoyed this course and look forward to continuing my education on the subject.
Instructores
Ralph Lydic, Ph.D.
Professor Emeritus, Molecular and Integrative Physiology, Professor Emeritus, AnesthesiologyUniversity of Michigan Medical School
Helen Baghdoyan, Ph.D.
Professor Emeritus, Anesthesiology, Professor Emeritus, Pharmacology, Professor of PsychiatryUniversity of Michigan Medical School
Acerca de University of Michigan
The mission of the University of Michigan is to serve the people of Michigan and the world through preeminence in creating, communicating, preserving and applying knowledge, art, and academic values, and in developing leaders and citizens who will challenge the present and enrich the future.
Preguntas Frecuentes
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