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The objective of this course is to give students the most up-to-date information on the biological, personal, and societal relevance of sleep. Personal relevance is emphasized by the fact that the single best predictor of daytime performance is the quality of the previous night's sleep. The brain actively generates sleep, and the first section of the course is an overview of the neurobiological basis of sleep control. The course provides cellular-level understanding of how sleep deprivation, jet lag, and substances such as alcohol, ,caffeine, and nicotine alter sleep and wakefulness. The second section of the course covers sleep-dependent changes in physiology and sleep disorders medicine. Particular emphasis will be placed on disorders of excessive sleepiness, insomnia, and sleep-dependent changes in autonomic control. Chronic sleep deprivation impairs immune function and may promote obesity. Deaths due to all causes are most frequent between 4:00 and 6:00 a.m., and this second section of the class highlights the relevance of sleep for preventive medicine. The societal relevance of sleep will be considered in the final section of the class. In an increasingly complex and technologically oriented society, operator-error by one individual can have a disastrous negative impact on public health and safety. Fatigue-related performance decrements are known to have contributed as causal factors to nuclear power plant failures, transportation disasters, and medical errors.
Globe

Cursos 100 % en línea

Comienza de inmediato y aprende a tu propio ritmo.
Beginner Level

Nivel principiante

Clock

Approx. 19 hours to complete

Sugerido: 5 hours/week
Comment Dots

English

Subtítulos: English
Globe

Cursos 100 % en línea

Comienza de inmediato y aprende a tu propio ritmo.
Beginner Level

Nivel principiante

Clock

Approx. 19 hours to complete

Sugerido: 5 hours/week
Comment Dots

English

Subtítulos: English

Syllabus - What you will learn from this course

1

Section
Clock
2 hours to complete

Unit 01 - Neurobiology Section: Course Introduction & Neurobiology of Sleep and Wakefulness (Part One) - (Standard Track & Honors Track)

This unit begins with a Course Overview video from Ralph Lydic, Ph.D., followed by the first portion of the Neurobiology of Sleep and Wakefulness lecture, delivered by Helen Baghdoyan, Ph.D. PLEASE NOTE: Only the Course Overview video, and the Getting Started and Syllabus readings are required for students who have chosen to engage in the Standard Track portion of the course content. Standard track students may also bypass all content in units 2, 3, and 4, and instead move directly to unit 5 after viewing the Course Overview video....
Reading
6 videos (Total 93 min), 4 readings, 1 quiz
Video6 videos
02.01 - Learning Points14m
02.02 - Defining Behavioral States8m
02.03 - Historical Overview: Brainstem & Forebrain17m
02.04 - Wake & REM: Monoamines17m
02.05 - Wake & REM: Acetylcholine17m
Reading4 readings
Getting Started10m
Syllabus10m
Help Us Learn More About You!10m
Lesson 2 Orientation10m
Quiz1 practice exercises
Did you Complete Lesson 2?2m

2

Section
Clock
2 hours to complete

Unit 02 - Neurobiology Section: Neurobiology of Sleep and Wakefulness (Part Two) - (Honors Track)

Unit 2 continues the lecture from Helen Baghdoyan, Ph.D. on the Neurobiology of Sleep and Wakefulness. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification....
Reading
5 videos (Total 73 min), 2 quizzes
Video5 videos
02.07: Wake & REM: Orexin17m
02.08: NREM: GABA14m
02.09: NREM: Adenosine 11m
02:10: Summary12m
Quiz2 practice exercises
Did you complete Lesson 03?2m
Unit 02 Honors Track Quiz - Neurobiology of Sleep and Wakefulness30m

3

Section
Clock
1 hour to complete

Unit 03 - Neurobiology: Mathematical Modeling of Sleep-Wake Regulation - (Honors Track)

Unit 3 continues the Neurobiology section of the content with a lecture from Victoria Booth, Ph.D. on the Mathematical Modeling of Sleep-Wake Regulation. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification....
Reading
10 videos (Total 67 min), 1 reading, 2 quizzes
Video10 videos
03.02 - Two Process Model 5m
03.03 - Sleep-Wake Flip-Flop Model5m
03.04 - Reciprocal Interaction Model 12m
03.05 - REM Sleep Flip-Flop Model4m
03.06 - Features for an Ideal Model of Sleep-Wake Regulation7m
03.07 - Introduction to Mechanistic Models of Sleep-Wake Regulation 3m
03.08 - Diniz Benh & Booth Model - Part I9m
03.09 - Diniz Benh & Booth Model - Part II 14m
03.10 - Conclusion 1m
Reading1 readings
Unit 03 Orientation10m
Quiz2 practice exercises
Did you Complete Lesson 5?2m
Unit 03 Quiz - Mathematical Modeling of Sleep-Wake Regulation10m

4

Section
Clock
1 hour to complete

Unit 04 - Neurobiology: Molecular Biology and Genetics of Sleep - (Honors Track)

Unit 4 closes out the Neurobiology section with a lecture from Chiara Cirelli, Ph.D. on Molecular Biology and the Genetics of Sleep. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification....
Reading
6 videos (Total 52 min), 2 quizzes
Video6 videos
04.02 - Wake Genes that are Associated with Energy Metabolism 7m
04.03 - Synaptic Plasticity is Genetically Modulated 7m
04.04 - Brain Glial Cells Influence States of Sleep and Wakefulness 9m
04.05 - Genetic Modulation of Human Sleep Phenotypes 8m
04.06 - Conclusion 11m
Quiz2 practice exercises
Did you complete Lesson 7?2m
Unit 04 Quiz - Molecular Biology and Genetics of Sleep10m

5

Section
Clock
2 hours to complete

Unit 05 - Medicine: Overview of Sleep Medicine - Ronald Chervin, M.D. - (Standard Track)

Unit 5 marks the beginning of the Medicine section of the course. This unit features an overview of Sleep Medicine from Ronald Chervin, M.D....
Reading
7 videos (Total 94 min), 1 reading, 1 quiz
Video7 videos
05.02 - Clinical Approach to Sleep Disorders10m
05.03 - Polysomnography 16m
05.04 - Classification of Sleep Disorders20m
05.05 - Obstructive Sleep Apnea 16m
05.06 - Testing for Obstructive Sleep Apnea6m
05.07 - Treatment for Obstructive Sleep Apnea, and Concluding Thoughts18m
Reading1 readings
Unit 05 Orientation10m
Quiz1 practice exercises
Unit 05 Quiz- Overview of Sleep Medicine10m

6

Section
Clock
1 hour to complete

Unit 06 - Medicine: Disordered Sleep and Breathing Alters Cardiovascular Health - (Standard Track)

Unit 6 continues the Medicine section of the course, featuring a lecture from Helena Schotland, M.D. exploring how Disordered Sleep and Breathing may alter Cardiovascular Health....
Reading
3 videos (Total 40 min), 1 reading, 1 quiz
Video3 videos
06.02 - Impact of Disordered Sleep and Breathing on Cardiovascular Health (Part 2)13m
06.03 - Outcomes of CPAP Therapy and Conclusions4m
Reading1 readings
Unit 06 Orientation10m
Quiz1 practice exercises
Unit 06 Quiz - Disordered Sleep and Breathing Alters Cardiovascular Health10m

7

Section
Clock
1 hour to complete

Unit 07 - Medicine: Sleep and Psychiatric Disorders - (Standard Track)

Unit 7 further continues the Medicine section of the course with a lecture on the relationship of Sleep and Psychiatric Disorders from Eric Nofzinger, M.D...
Reading
8 videos (Total 68 min), 1 reading, 1 quiz
Video8 videos
07.02 - What Goes to Sleep?13m
07.03 - Sleep Alterations Associated with Specific Psychiatric Disorders20m
07.04 - Bipolar Disorder and Schizophrenia4m
07.05 - Anxiety Disorders4m
07.06 - Substance Use Disorders 3m
07.07 - Insomnia4m
07.08 - Interventions for Insomnia6m
Reading1 readings
Unit 07 Orientation10m
Quiz1 practice exercises
Unit 07 Quiz - Sleep and Psychiatric Disorders10m

8

Section
Clock
1 hour to complete

Unit 08 - Medicine: Insomnia: Causes and Consequences - (Standard Track)

Unit 8 further continues the Medicine section of the course with a lecture from Christopher Drake, Ph.D. on the causes and consequences of Insomnia....
Reading
4 videos (Total 49 min), 1 reading, 1 quiz
Video4 videos
08.02 - Consequences of Insomnia 11m
08.03 - Causes of Insomnia 16m
08.04 - Insomnia and its Relation to Hyperarousal12m
Reading1 readings
Unit 08 Orientation10m
Quiz1 practice exercises
Unit 08 Quiz - Insomnia: Causes and Consequences10m

9

Section
Clock
1 hour to complete

Unit 09 - Medicine: Treatments for Insomnia - (Standard Track)

Unit 9 further continues the Medicine section of the course with a lecture from J. Todd Arendt, Ph.D. on the range of available treatments for Insomnia....
Reading
9 videos (Total 48 min), 1 quiz
Video9 videos
09.02 - Treatment Options for Insomnia4m
09.03 - BzRA Hypnotics5m
09.04 - Abuse Liability of Hypnotic Agents5m
09.05 - Pharmacological Treatments for Insomnia3m
09.06 - Nonpharmacological Treatments for Insomnia5m
09.07 - How CBT-I Works6m
09.08 - Pharmacological Treatments for Insomnia Part III6m
09.09 - Summary 2m
Quiz1 practice exercises
Unit 09 Quiz - Treatments for Insomnia10m

10

Section
Clock
1 hour to complete

Unit 10 - Medicine: Sleep and Anesthesia - (Standard Track)

Unit 10 brings the Medicine section of the course to a close with a lecture on Sleep and Anesthesia delivered by George Mashour, M.D....
Reading
4 videos (Total 33 min), 1 quiz
Video4 videos
10.01 - Sleep and Anesthesia: Shared Phenotype and Shared Mechanism? 14m
10.02 - Sleep and Anesthesia: Shared Function? 17m
10.03 - Summary1m
Quiz1 practice exercises
Unit 10 Quiz - Sleep and Anesthesia10m

11

Section
Clock
2 hours to complete

Unit 11 - Society: Circadian Rhythms, Sleep, and Health - (Standard Track)

Unit 11 kicks off the Society section of the course with a lecture on Circadian Rhythms, Sleep, and Health from Theresa Lee, Ph.D....
Reading
5 videos (Total 88 min), 1 reading, 1 quiz
Video5 videos
11.02 - Sleep Occurs as a Circadian Rhythm 18m
11.03 - Changes in Sleep Rhythms Across the Lifespan (Part 1) 21m
11.04 - Changes in Sleep Rhythms Across the Lifespan (Part 2) 15m
11.05 - Circadian Rhythms and Sleep Hygiene10m
Reading1 readings
Unit 11 Orientation10m
Quiz1 practice exercises
Unit 11 Quiz - Circadian Rhythms, Sleep, and Health10m

12

Section
Clock
1 hour to complete

Unit 12 - Society: Daytime Sleepiness and Sleep Need - Thomas Roth, Ph.D. (Standard Track)

Unit 12 wraps up the final section of the course and the Society section of the content with a lecture on Daytime Sleepiness and Sleep Need by Thomas Roth, Ph.D....
Reading
4 videos (Total 46 min), 3 readings, 1 quiz
Video4 videos
12.02 - How is Sleepiness Measured? 10m
12.03 - How Many People in our Society are Sleepy? 18m
12.04 - What are the Causes of Daytime Sleepiness? 13m
Reading3 readings
Unit 12 Orientation10m
Farewell for Now10m
Post-Course Survey10m
Quiz1 practice exercises
Unit 12 Quiz - Daytime Sleepiness and Sleep Need10m
4.8

Top Reviews

By JQJan 3rd 2018

Excellent course! A great review on stuff I should have remembered but of course have forgotten as I've aged. My thanks to those organizing and teaching the course! Dr Quincy

By TMMar 4th 2018

Very good course! I liked it a lot not only on professional perspective, but also personally to understand the importance of a good sleep and how everything is related.

Instructors

Avatar

Ralph Lydic, Ph.D.

Professor Emeritus, Molecular and Integrative Physiology, Professor Emeritus, Anesthesiology
Avatar

Helen Baghdoyan, Ph.D.

Professor Emeritus, Anesthesiology, Professor Emeritus, Pharmacology, Professor of Psychiatry

About University of Michigan

The mission of the University of Michigan is to serve the people of Michigan and the world through preeminence in creating, communicating, preserving and applying knowledge, art, and academic values, and in developing leaders and citizens who will challenge the present and enrich the future....

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