So we finished talking about the demographics and
what we might collect in terms of the
one time data about information and, and the
information that we might collect on their baseline visit.
we didn't talk yet about how we might collect the
data for the, for the thermal stimuli for that baseline visit.
But, we'll kind of, kind of cover that as we look at what we might
record and how we might measure information
we're collecting in every single follow up visit.
In this case you remember we're taking the
individual, were, we're randomizing at the beginning of the
study for that individual how they will have a
drug combinations will be administered from visit to visit.
And, and each given visit we going to pick the number out of a hat as well.
And we going to, we going to choose a random
combination of, of pain sequences to, to put these
individuals through.
So let's talk about the the measurements at the individual visit level.
So, so we bring patient and we, we know what drug combination
they're in because that was predefined at the beginning of the study.
We, we gave them that drug combination, we wait for the appropriate amount of time.
We've got everything set up, it's consistent from
patient to patient and from visit to visit.
This thermal stimuli.
And what we're going to do, is we going to run
through a sequence of of, of.
providing this thermal stimuli to these individuals' forearms.
And we're going to do the thermal, thermal sequences in a
randomized order as, as we see here on the left.
This Combo one equals 37, 49 and then 51 degrees.
and then the next one might be 37, 51 and 49 etcetera.
So that we're not.
following the same protocol for the same individual
within a given visit or, or across visits.
So, so once we start administering those those, those rods to
the, to the forearm for five seconds, then we're going to ask them.
We're going to measure both the sensory pain,
the intensity as well as the effective pain.
And we're going to do those according to the way
the study did it and the way the study published.
We'll do those in, in sort of separate components.
So,
so we administer the pain in the first
three sequences and we'll ask about the sensory pain.
How, how intense is this?
And, and, then we'll go, we'll give a rest,
we'll come back and we'll, and we'll record again.
the affective pain that, that we're administering there.
We'll do that four cycles and that way we've got.
two sets of measurements on each pain type.
and for each of those pain types we have
two measurements per per, per, temperature.
Two measurements of sensory at 37 degrees to, to,
to at 51 degrees for the affective pain etcetera.
So we'll have a pile of data there as we, as we get done by measuring
these visual analogue scales, measuring how, how they're
indicating their pain levels on those visual analogue scales.