Everyone knows that energy is essential for sustaining life. How can you define energy in life? Have ever thought about ways of how carbohydrates like glucose from your diet can be used for extracting energy? A scientific field that focuses on energy production and flow though living cells and organisms is called bioenergetics. Energy metabolism covers various biochemical ways of energy transformation and regulatory mechanisms of over thousands chemical reactions. Without fine control of those metabolic processes, cells and organisms cannot maintain activities linked to life. This 7 week-course will give you a clear introduction to the basic fundamentals of energy metabolism. We will first establish the concept of energy metabolism and subsequently examine biochemical steps involved in energy production from glucose oxdiation as well as glucose synthesis via photosynthesis. We will also learn about metabolic reactions related to fat as well as regulatory actions among different organs. Finally, dysregulated energy metabolism in pathological conditions such as diabetes and cancer will be discussed. Everyone knows that energy is essential for sustaining life. How can you define energy in life? Have ever thought about ways of how carbohydrates like glucose from your diet can be used for extracting energy? A scientific field that focuses on energy production and flow though living cells and organisms is called bioenergetics. Energy metabolism covers various biochemical ways of energy transformation and regulation of thousands of chemical reactions. Without fine regulation of those metabolic processes, cells and organisms cannot maintain activities linked to life. This 7 week-course will give you a clear introduction to the basic fundamentals of energy metabolism. We will first establish the concept of energy metabolism and subsequently examine biochemical processes involved in energy production as well as photosynthesis. We will also learn about metabolic reactions related to fa as well as regulatory actions among different organs. Finally, dysregulated energy metabolism in pathological conditions such as diabetes and cancer will be discussed.
6. Microbiota and energy metabolism
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Del curso dictado por Korea Advanced Institute of Science and Technology
Biochemical Principles of Energy Metabolism
26 calificaciones
Korea Advanced Institute of Science and Technology
26 calificaciones
De la lección
Module 7: Energy Homeostasis in your body
Conoce a los instructores
Seyun KimAssistant Professor
Department of Biological Sciences
Hello everyone. Welcome back to my Coursera class,
Biochemical Principles of Energy Metabolism.
This is a last session of entire class.
Okay? Final session of week seven, so last class.
So I just truly wish you could enjoy the biochemical basis of bioenergetics,
and I hope you could obtain fundamental knowledges
on the significance of energy metabolism in normal physiology,
as well as the pathophysiology like diabetes and cancer and so on.
So let me begin with the last session.
It's about Microbiota.
Microbiota. So, the human body is
actually not just compose of not just human cells.
Human body is many other living organisms and bacteria,
actually, being populated in human and human body.
So microbial community inhabiting a specific environment is so-called microbiota.
It's like a definition.
Okay? So think about microbial and human relationship.
Many bacteria living in your oral cavity,
or skin, vagina, or gut, right?
So it's kind of mutual benefits identified for a long time.
In particular, in your gut,
like cellular density increases along the length of the gut,
and the microbiota living in your gut is
the densest and most diverse community and even in the whole human body.
Okay? 10 to the 14th bacteria actually living in your gut.
And the type of bacteria is
more than 1000 different types of bacterial species actually so far identified.
So human gut microbiota metabolic interactions are very,
very complex and very, very dynamic.
Okay? And those dynamic relationship
can be changed over time depending on the diet you have,
depending on the lifestyle,
and types of disease you have,
or depending on the antibiotics.
Antibiotics means the removal of your gut microbiota.
Okay? So I'm going to talk about the importance of microbiota in
the regulation of bioenergetics of human.
So Microbiota dysbiosis. So what is that?
Dysbiosis. So perturbation of
the normal healthy microbial profile is defined as microbiota dysbiosis.
So simply speaking, good gut bacteria levels
decreased and rather pathologically critical pathobionts,
those bacteria levels will be increased and then in this imbalance situation,
many human diseases can be indeed developed like dental plaque,
bacterial vaginosis, psoriasis, a skin disease, atopic dermatitis.
But more importantly, gut microbiota dysbiosis can
lead to metabolic syndromes like obesity and type 2 diabetes.
In particular, I'm going to show the data.
Around 90 percent of the gut microbial community is actually indeed
dominated by two members of phyla, Bacteroidetes and Firmicutes.
And many correlation studies and biochemical analysis
showing that the ratio of Firmicutes to Bacteroidetes when
that ratio is increased that means when Firmicutes is somehow dominate in
your gut is more like obesity and related metabolic syndrome can be developed. Okay?
So, and gut microbiota and Bioenergetics.
How those bacteria can influence the host human physiology,
in particular, human metabolism,
and complex carbohydrates, for example, dietary fibres?
I introduced many like enzymes involved in intestinal digestion system.
So some dietary fibres,
humans do not have appropriate enzymes, but bacteria have.
So gut micro-bacteria can further metabolize,
fully metabolize those dietary fibres in your colon to oligosaccharide,
monosaccharide or whatever, and finally, being fermented to,
in this case, short-chain fatty acid called SCFA.
Examples include acetate, propionate and butyric acid.
And those short-chain fatty acids can be produced inside your gut,
and then those SCFA can be observed in the colon.
Okay? So without those gut microbiota,
these dietary fibre may be just excreted and moved away,
right? Through the feces.
But in the presence of those gut microbiota,
short-chain fatty acids will be metabolized and supplied to your cells and ultimately,
energy harvest efficiency will be dramatically increased.
So bioenergetically, energy harvest is very, very increased.
And in parallel, those acetate,
propionic acid or a butyrate can act as a signaling molecules.
There are some examples and those fatty acids can
affect host to human cell gene expression,
and in some cases,
they can activate gut-derived hormone like a GLP hormone secretion.
So those bacterial drive to metabolite SCFA can influence
the metabolic efficiency as well as host cellular signaling networks.
So on top of that,
there is another layer of microbiota-dependent metabolism.
So bile acid metabolism.
What is bile acid?
Bile acid is the chemicals produced from cholesterol,
and in particular, fat digestion.
This bile acids are very, very important, right?
For facilitate fat digestion.
But interestingly, this bile acid can be further metabolized
inside the lumen of colon and the secondary bile as it can be developed, can be produced.
And then secondary bile acid metabolism is mediated by gut microbiota.
And this type of secondary bile acids are produced and those bile acids,
they are acting as a specific signaling molecules and some receptors will be affected,
in particular, like the brown adipose tissue and muscles.
When those secondary bile acids act upon those tissues,
an energy expenditure will be increased and finally,
diet-induced obesity can be increased.
This is another important layer of gut microbiota.
In this case, bile acids depend on metabolic actions.
So, in that sense,
it's like the scientists are working on the bioenergetics.
They're primarily focusing on the human cell or biochemistry or human cell metabolism.
But recently, many people are being interested
in probiotics or prebiotics or the gut microbiota dependent metabolic regulations.
So probiotics, definition-wise is the live microorganisms.
So simply speaking, we can use a good gut microbiota, Lactobacillus, or Bifidobacterium.
When we just establish
those good bacteria a living environment in the gut of humans,
then we can have many medical benefits.
So, those bacteria can compete with other pathogenic bacteria
or interfere with the bad bacterial life cycles,
or they can directly attack or inhibit
the pathogenic bacteria or they
are just antagonistically live together inside the human gut.
And the other approach is prebiotics.
Prebiotics is just non-digestible food ingredients.
And actually, when they are efficiently utilized by
a gut microbiota in specific good microbial species,
can be dominant and then
favor gut like a microbial community in the host colon.
This is another area of
active or investigation in the regulation of human energy metabolism.
So finally, I'm going to wrap up these gut microbiota dependent functions.
So, in the very beginning,
we have to think about host energy metabolism.
So gut microbiota can break down diets like indigestible fibers or other types of
diet that humans cannot use
and produce gut microbiota specific metabolite and ultimately,
those are used for human bioenergetics.
And secondly, protection.
So, resident good microbiota,
gut bacteria like a bacteria [inaudible] protect the host from pathogenic population.
The third one is immune control. I have no time to explain
this topic but this is also very,
very important action of gut microbiota.
A good bacteria in your gut can influence
the development and function of immune cells, immune cells,
by excreting many bacterial substances and ultimately,
help the strong and tight and healthy gut epithelial tissues.
These are proposed functions of gut microbiota.
Obviously, right now, many scientists are trying to fully
understand the actual biochemical and molecular and physiological relationship
between gut microbiota and the host.
I mean, the human, in the context of metabolism as well as any other types of diseases.
All right, I'm trying to wrap up this course by
showing the list of topics.
So, in the very beginning,
we studied about the introduction of metabolism and what energy is,
and so what is ATP,
how those ATP molecules are utilized in our system,
and we reviewed the metabolic organs and the basic concept of enzymes,
and we began with the glucose digestion and
full catabolic reactions called the cellular respiration.
And then to make sure this glucose is not just given for free easily,
plant cells undergo miraculous biochemical event called photosynthesis.
And I also emphasized the importance of fat metabolism.
So, glucose and fat.
So, in addition to biochemical details involved in energy extraction,
I mean ATP synthesis,
we looked at physiologic inter-organ relationship.
In particular, I emphasized the insulin signalling
actions to understand diabetes mellitus.
And then lastly, I believe I tried to introduce different types of bioenergetics.
Mediated physiologic processes like
starvation-induced metabolic responses, stress responses,
exercise and alcohol metabolism and what types
of biochemical adaptations are available for tumor cells and finally,
the importance of gut microbiota.
So, as I introduced in the very beginning of this course,
this course is about basic conceptualization of bioenergetics.
So, if you're really interested in the biochemical details,
very details of each enzymatic actions,
please look up to Advanced Level of Biochemistry textbook.
I think like this biochemistry textbook,
and then you can have those biochemical details by yourself.
I just truly wish you could enjoy the content of my course,
and I hope you could nicely build up the basic fundamental principles of bioenergetics.
And I really appreciate
your support and passion and I thank you very much for listening to,
watch my video clips and my course.
If you have any questions,
feel free to send me e-mail and I'm going
to respond with best answers. Thank you very much.
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