So far the authors have made a very compelling case for
the role of HIPK2, and HIV apoptosis and
also in the role of the epithelial to mesichimal transition.
But we haven't really seen so, any NBVO data.
And this is where Figure 6 comes in, where we actually see
what is the effect of reducing the levels of HIP Kinase
2 in [INAUDIBLE] or effective with HIV.
And one of the, the key panels here
is looking at the level of albionin and
creatine ratio in the urine of these mice.
And they have measured the amount of protein
in their urine as a measure of kidney function.
And we have four groups.
The wall type, the knockout, no to little expression of HIP kinase,
the Tg26 and also the,
the Tg26 that are also low expressors of HIP kinase too.
And, as expected, the Tg26 mice exhibit
very prominent proteinuria, or protein in their urine and
this decrease in function appears to be
significantly reduced in animals that have low expression
of HIPK2, suggesting that reducing the activity of
HIPK2 can have a protective effect in HIVAN.
>> And having low levels of HIPK2 can
protect against proteinuria, suggesting an enhanced filtration and kidney function.
So, we're going to conclude this lecture with a couple of take home messages.