Cerebellar Laterality

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Del curso dictado por The University of Chicago

Understanding the Brain: The Neurobiology of Everyday Life

624 calificaciones

The University of Chicago

Understanding the Brain: The Neurobiology of Everyday Life

624 calificaciones

Learn how the nervous system produces behavior, how we use our brain every day, and how neuroscience can explain the common problems afflicting people today. We will study functional human neuroanatomy and neuronal communication, and then use this information to understand how we perceive the outside world, move our bodies voluntarily, stay alive, and play well with others.

De la lección

Motor Modulation

You should now have an understanding of how muscles function to initiate movements. However, the brain requires more than just the cerebral cortex to determine what movements to perform and to make those movements smooth and guided. This module, we'll explore the cerebellum and the basal ganglia, fascinating structures that play a major role in movement. You'll also learn how these brain regions are involved in motor learning and disease.

The Data-Driven Cerebellum6:25

The Purkinje Cell4:05

Cerebellar Functions5:48

Cerebellar Topography5:49

Cerebellar Laterality3:20

Efference Copy and Sensory Reafference6:22

Conoce a los instructores

Peggy Mason
Professor
Neurobiology

[MUSIC]

As you know, if there's a stroke in the cerebral cortex, we're

going to look for problems that are on the other side of the body.

So that my left motor cortex is controlling my, the right

muscles, my muscle, my movements on the right side of my body.

And information about touch and pain and temperature from the right

side of my body is ending up on the left cerebral cortex.

Now, the cerebellar core, cerebellum works differently.

It, actually operates on the same side of the body.

So, let's just understand how that works.

Information comes in from the spinal cord, all

this sensory information comes in from the same side.

Information from the cerebral cortex comes down into the

pons and then crosses the midline to come into the cerebellum.

And information from the cerebellum leaves to go to the

midbrain on the other side of the body, and to go to the

thalamus in order order to go back to the cerebral cortex.

So a lesion on the left side of the the cerebellum is

going to affect movement on the left side of the body.

So, ipsilateral, same side.

Now as you, as you know, the cerebellum

is actually attached through these Peduncles, and so you

could damage the cerebellum, or you could just

damage the peduncles, it would have the same effect.

Since everything has to come in and out of the peduncles, a damage

to the peduncles will have the same effect as damage to the whole cerebellum.

So let's imagine that we have a stroke, a

pretty devastating stroke, such as the one that Bubby suffered.

What we would see, but let's say it's less devastating than what Bubby suffered

and that what we're doing is we're, we're losing half of the pons.

What you would see here is an ataxia on the same side

of the body, but a paralysis on the opposite side of the body.

So let's just make sure that that's clear.

That what we just said is the cerebellum operates on the same side of the body.

So the ataxia, the dysfunction of the cerebellum is

going to be on the same side of the body.

But this information from the cerebral cortex that is

en route to

the spinal cord is going to cross and so the information that's cut from the

cerebral cortex on the left is actually going to effect movement on the right.

So there will be a voluntary paralysis on the right with a left-sided ataxia.

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