The Mayo Clinic and Arizona State University Alliance for Health Care has developed innovative Science of Health Care Delivery training programs which introduce scientific approaches to quality improvement for patient care and population health, while also examining ways to reduce health costs. The full training, which explores key concepts in the Science of Health Care Delivery and why it is critically important to future patient care, can be used by health care professionals or as curriculum for aspiring care providers. By the end of this introductory course, learners will recognize the how education in the Science of Health Care Delivery can improve and enhance the quality of provider care, health care systems and patient health. The overview course consists of a multimedia introduction to Science of Health Care Delivery domains, followed by video segments where learners meet a patient and caregivers who embody or apply new knowledge, skills and attitudes learned from the Science of Health Care Delivery. An expert reflection after each video presentation reinforces the domain’s concepts. Learners can seek more information into this dynamic field with the additional resources provided at the end of the course.