As a function of this voltage clamp, so again, like here, we voltage clamp to

this value, to this value, to this value, to this value And Hodgkin Huxley recorded

that conductance of the sodium for this value, for this value, for this value, of

depolarization. And here again, you see something

interesting. First again, you see that this sodium

conductance responds fast. So as soon as you have voltage clamp,

very early on, you get a conductance change.

Very early on. This is why we call it fast conductance

change. This is a slow conductance change for the

potassium, this is fast conductance change for the sodium, fast conductance

change. And again, like here, when, when you,

when the depolarization is more and more extreme you get more and more

conductance. You get more and more conductance.

So the conductance becomes stronger or larger with depolarization.

From minus 40 millivolts to minus 20 to zero to even plus 20.

You get more and more sodium conductance. This is in the beginning.

But still, you continue to voltage climb, and the conductance fades away.

Somehow it inactivates, and it disappears during the voltage climb.

So this is again this conductance that is early which enables very early on to

carry sodium channels, sodium current inside the cell, early on.

But after some times, this conductance turns off, and there is no sodium current

anymore, although you continue the voltage clamp.

This is not the case for the potassium that continues to be open as long as the

voltage clamp descends to a given depolarization.

So these are the different two conductances that underlying, the voltage

sensitivity of the membrane of the axon. So, I'm, I'm summarizing here.

The slow, the slow potassium current, or potassium conductance, does not

inactivate during voltage clamp. Know that the k conductants rises slower.

Then it attenuates, and this was important for Hodgkin Huxley later on to

write down the appropriate equation to describe these curves.

So it's a slowing growing curve and faster attenuating curve at the end of

the voltage clamp. And you see this sodium current this

early sodium current, or conductance, inactivates during voltage climb.

It's early, so this is the first current that flows when there is voltage change,

it's a sodium current, but this sodium current, early sodium current,

inactivates during voltage climb, unlike the potassium current.