Peri-Operative Evaluation and Fitness

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Del curso dictado por University of Michigan

Thoracic Oncology

119 calificaciones

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University of Michigan

Thoracic Oncology

119 calificaciones

Thoracic malignancies are major, global health problems. Lung cancer is the most common cancer and cause of cancer death in the world, with more than 1.5 million deaths per year. More Americans will die from lung cancer each year (approximately 159,480) than from colon, breast, pancreatic, and prostate cancer combined (approximately 158,630), the next most common causes of cancer death. Esophageal cancer is the 6th most common cause of cancer deaths worldwide, and the 4th most common cause in developing nations. This course will provide a comprehensive, multidisciplinary introduction to state of the art approaches in the care of patients with thoracic malignancies, including various types of lung cancers and esophageal cancers. Didactic material will cover epidemiology, screening and diagnosis, staging, imaging, radiation therapy, systemic therapy, surgery, psychiatry, and patient support topics. This is an on-demand course with integrated learning units that are focused on specific topics. Each unit contains several video lectures with interactive questions and is followed by a short quiz. Prerequisites: None required although basic medical training in some field related to thoracic oncology would be helpful.

De la lección

Non-Small Cell Lung Cancer and Tracheal Cancer: Therapeutics

After reviewing this unit, the learner will understand basic principles regarding:

Introduction to Radiation Therapy13:10

Definitive Radiation Therapy For Stage I NSCLC13:00

Definitive Radiation Therapy For Locally Advanced NSCLC21:33

Palliative Radiation Therapy For Metastatic Lung Cancer17:45

Stereotactic Body Radiation Therapy (SBRT) For Oligometastatic Lung Cancer10:28

Adjuvant Therapy for Non-Small Cell Lung Cancer14:58

Combined Modality Therapy For Locally Advanced Non-Small Cell Lung Cancer17:01

Overview of Stage IV Non-Small Cell Lung Cancer14:05

Chemotherapy for Stage IV Non-Small Cell Lung Cancer30:23

Immunotherapy for Non-Small Cell Lung Cancer19:03

Molecularly Targeted Therapy for Non-Small Cell Lung Cancer28:03

FDG-PET Imaging of Non-Small Cell Lung Cancer: Treatment Response Monitoring9:52

Early Stage: Surgery - Lung Resection - Wedge, Segmentectomy, Lobectomy15:01

Complex Lung Resection: Sleeve Lobectomy and Pneumonectomy8:49

Thoracotomy Versus Minimally Invasive Approaches for Lung Cancer Resection11:39

Palliative Surgery For Stage IV Lung Cancer - Tracheal and Pleural Disease9:36

Chest Wall Resection16:55

Metastasectomy of Cancer Spread to the Lung7:06

Peri-Operative Evaluation and Fitness6:41

Complications After Lung Cancer Surgery20:06

Conoce a los instructores

Dr. Leslie Eisenbud Quint
Course Co-director, Professor of Radiology and Professor of Surgery, Section of Thoracic Surgery
Medical School
Dr. Rishindra Reddy
Course Co-director, Assistant Professor of Surgery, Section of Thoracic Surgery
Medical School
Dr. Gregory Kalemkerian
Course Co-director, Professor of Medicine, Division of Hematology/Oncology
Medical School
Thoracic Oncology team at the University of Michigan

Hello, I'm Phil Carrott,

one of the thoracic surgeons in the University of Michigan.

And I'm here to discuss perioperative evaluation and

fitness in thoracic oncology patients.

This will mainly focus on lung cancer but we'll have the application to any

sort of patient in thoracic oncology that is to be prepared for surgery.

So fitness for surgery, the PFTs and VO2Max, cardiac evaluation,

and pre-operative preparation for better fitness are objectives today.

So what pulmonary function parameter most actually predicts operative fitness?

Is it the FEV1?

Is it the FVC?

DLCO?

Or the FEV1/FVC ratio?

I'll be thinking about this during the lecture.

So for lung resection, general guidelines use 40% of predicted for

FEV1 and DLCO as cut-offs for surgery.

The absolute FEV1 remaining after resection should be above 800 milliliters

on average, in order to have adequate lung function post-operatively.

For PFTs, the general guidelines for surgery,

in general, for LVRS should be greater than 20% of predicted.

For lobectomy, greater that 40% of predicted.

And for pneumonectomy, greater than 60% of predicted.

Although other factors can predict fitness better than just these numbers.

FEV1 is dependent on airway health and the physical strength of the patient.

If they're not trying hard enough, that could give you a sort of false low FEV1.

The DLCO shows the alveolar health, so how good the tissue is.

And further testing should be done on values below 60% of

predicted to ensure good patient fitness for surgery.

So V/Q scans can help predict the contribution of

the planned resection area.

Specifically if the lobe is collapsed,

that is not really contributing to the PFTs in the first place.

Cardiopulmonary exercise testing is also useful,

particularly in borderline patients.

The V/Q scan will show contribution of each lobe but

should be carefully evaluated as zones on the scan are not per lobe.

So this is an example of a relatively borderline V/Q scan.

You can see the left lung is only approximately 22%

of the total perfusion and ventilation.

And if a left pneumonectomy were considered in this patient, they would

probably do fairly well, as long as their PFTs for the right lung are adequate.

So in marginal patients,

VO2Max should be above 15 milliliters per kilogram per minute, or 40% of predicted.

And this can trump marginal PFTs if somebody has a good functional status but

for some reason, did not do well on their pulmonary function test.

So general operative fitness can also be assessed in the office and

improved by the patient pre-operatively.

Stair walking is a good test of both coordination and

fitness that a patient that is uncoordinated may have more trouble

post-operatively if they're very old or in poor shape.

A six minute walk test is a good test routinely done in

a pulmonologist's office.

You'll spend a couple of minutes on pre-habilitation which is

the exercise improvement before surgery.

A relatively new idea that we've been doing for

some time at the University of Michigan.

And incentive spirometer training should be carried out pre-operatively rather

than post-operatively, so the patients know how to use the incentive spirometer.

In pre-operative preparations, so our routine is for pre-habilitation,

is increasing physical activity.

And patients can do this just by walking one to three miles every day.

Using the incentive spirometer every day.

And making this routine, so that they are in better shape,

especially if they're sedentary to some extent.

Reviews showed that there are trends to better outcomes,

better quality of life, and better aerobic capacity in patients that undergo this

simple pre-operative preparation.

And I have just a couple slides on cardiac clearance.

So the Journal of JACC guidelines.

Basically, if the patients are high risk for some reason or

a have a poor functional capacity, they should be assessed further.

As the risk factors, history of myocardial infarction, history of heart failure,

history of a stroke, diabetes, or renal failure with a creatinine over two.

Should all have further workup as a stress test of some sort before surgery.

They prefer the exercise stress if possible.

Alternatives in patients that may not be able to undergo an exercise stress

test are radionuclear stress or stress echo or if the EKG is uninterpretable.

In asymptomatic patients,

it can be indicated to do exercise stress if it's a high risk surgery.

Most complex surgery and thoracic oncology, such as a pneumonectomy or

esophageal cancer, should probably undergo cardiac testing for almost any patient.

Other testing in asymptomatic patients may be appropriate,

if they're unable to walk or there's some other complicating factor.

So in pulmonary function testing,

what parameter most accurately predicts for operative fitness?

Is it FEVI, FVC, DLCO or the ratio?

It is in fact, DLCO predicting more accurately than FEV1.

But all of these parameters should be taken into account

when you're assessing patients pre-operatively.

So for fitness, for surgery, PFTs and exercise stress testing

are good starting points in patients to undergo in complex surgery.

Pre-habilitation can minimize pulmonary complications especially pneumonia and

stopping smoking.

And marginal operative candidates should have

further tests to more accurately assess fitness.

Thank you.

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