Acerca de este curso: Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030. Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done. In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient.
Para quién es esta clase: This course should be helpful to anyone who wants to develop a deeper understanding of cancer metastasis. It should be useful to undergraduate students who are interested in exploring the science of cancer and to health care providers, data managers, and educators who need a more thorough understanding of metastatic cancer and how it affects individuals. The course is NOT designed for patients seeking treatment guidance.
Creada por: Johns Hopkins University
Enseñado por: Kenneth J. Pienta, M.D., The Donald S. Coffey Professor of Urology
The James Buchanan Brady Urological Institute
Enseñado por: Jelani Zarif, Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
Enseñado por: Sarah Amend, Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
Enseñado por: Haley Axelrod, Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
Enseñado por: Kenneth Valkenburg, Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
| Nivel | Beginner |
| Compromiso | 3 weeks, 1.5 hours per week |
| Idioma | English |
| Cómo aprobar | Aprueba todas las tareas calificadas para completar el curso. |
| Calificaciones del usuario |
Programa
SEMANA 1
History and Overview of Metastasis
In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.
5 videos
- Vídeo: Introduction to History and Overview of Metastasis
- Vídeo: History and Overview of Metastasis
- Vídeo: History of Metastasis Theory
- Vídeo: Introduction to the Sequential Steps of Metastasis
Calificado: History and Overview of Metastasis
Primary Tumor Growth and Neoangiogenesis
In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.
5 videos
- Vídeo: Tumor formation: Uncontrolled cell division
- Vídeo: The role of mutations in primary tumor formation and evolution
- Vídeo: Neoangiogenesis: new blood vessel formation in cancer
- Vídeo: The primary tumor microenvironment: what else affects primary tumor growth?
Calificado: Primary Tumor Growth and Neoangiogenesis
SEMANA 2
EMT / Invasion / Intravasation
During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.
4 videos
- Vídeo: Epithelial-mesenchymal transition, invasion, and intravision
- Vídeo: Local Tumor Invasion
- Vídeo: Intravasation
Calificado: Invasion and Intravasation
Survival in the Circulation and Extravasation
We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.
6 videos
- Vídeo: Glossary of Terms
- Vídeo: The Circulation
- Vídeo: How cancer cells survive while in circulation
- Vídeo: Becoming a circulating tumor cell (CTC) and evading immune detection
- Vídeo: Homing to a new site in the body and extravasation
Calificado: Survival in the Circulation and Extravasation
SEMANA 3
Dormancy and Secondary Tumor Growth
In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.
6 videos
- Vídeo: Metastatic homing
- Vídeo: Evidence for cancer dormancy
- Vídeo: Cancer dormancy defined
- Vídeo: Properties of dormant cancer cells
- Vídeo: Secondary outgrowth
Calificado: Dormancy and Secondary Tumor Growth
Morbidity and Mortality Associated with Metastasis
In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.
4 videos
- Vídeo: Distribution of Metastasis: Where do cancers spread?
- Vídeo: Cancer Syndromes
- Vídeo: Congratulations
Calificado: Morbidity and Mortality Associated with Metastasis
Preguntas Frecuentes
Cómo funciona
課程作業
每門課程都像是一本互動的教科書，具有預先錄製的視頻、測驗和項目。
來自同學的幫助
與其他成千上萬的學生相聯繫，對想法進行辯論，討論課程材料，並尋求幫助來掌握概念。
證書
獲得正式認證的作業，並與朋友、同事和雇主分享您的成功。
Creadores
Johns Hopkins University
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
Tarifa
| Comprar curso | |
|---|---|
| Accede a los materiales del curso | Disponible |
| Accede a los materiales con calificación | Disponible |
| Recibe una calificación final | Disponible |
| Obtén un Certificado de curso para compartir | Disponible |
Calificaciones y revisiones
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