Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030.
Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done.
In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient.
Understanding Cancer Metastasis
ofrecido por
Universidad Johns Hopkins
Acerca de este Curso
4.8
530 calificaciones
Habilidades que obtendrás
CancerMolecular BiologyCancer BiologyCancer Stem Cells
Programa - Qué aprenderás en este curso
Semana
1History and Overview of Metastasis
In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.
5 videos (Total 18 minutos), 1 quiz
5 videos
Introduction to History and Overview of Metastasis48s
History and Overview of Metastasis4m
History of Metastasis Theory4m
Introduction to the Sequential Steps of Metastasis5m
1 ejercicio de práctica
History and Overview of Metastasis20m
Primary Tumor Growth and Neoangiogenesis
In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.
5 videos (Total 36 minutos), 1 quiz
5 videos
Tumor formation: Uncontrolled cell division12m
The role of mutations in primary tumor formation and evolution11m
Neoangiogenesis: new blood vessel formation in cancer5m
The primary tumor microenvironment: what else affects primary tumor growth?6m
1 ejercicio de práctica
Primary Tumor Growth and Neoangiogenesis24m
Semana
2EMT / Invasion / Intravasation
During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.
4 videos (Total 18 minutos), 1 quiz
4 videos
Epithelial-mesenchymal transition, invasion, and intravision9m
Local Tumor Invasion4m
Intravasation2m
1 ejercicio de práctica
Invasion and Intravasation14m
Survival in the Circulation and Extravasation
We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.
6 videos (Total 31 minutos), 1 quiz
6 videos
Glossary of Terms2m
The Circulation4m
How cancer cells survive while in circulation4m
Becoming a circulating tumor cell (CTC) and evading immune detection10m
Homing to a new site in the body and extravasation8m
1 ejercicio de práctica
Survival in the Circulation and Extravasation24m
Semana
3Dormancy and Secondary Tumor Growth
In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.
6 videos (Total 31 minutos), 1 quiz
6 videos
Metastatic homing5m
Evidence for cancer dormancy4m
Cancer dormancy defined8m
Properties of dormant cancer cells6m
Secondary outgrowth4m
1 ejercicio de práctica
Dormancy and Secondary Tumor Growth20m
Morbidity and Mortality Associated with Metastasis
In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.
4 videos (Total 27 minutos), 1 quiz
4 videos
Distribution of Metastasis: Where do cancers spread?10m
Cancer Syndromes14m
Congratulations1m
1 ejercicio de práctica
Morbidity and Mortality Associated with Metastasis20m
50%
comenzó una nueva carrera después de completar estos cursos
33%
consiguió un beneficio tangible en su carrera profesional gracias a este curso
12%
consiguió un aumento de sueldo o ascenso
Principales revisiones
por RW•Jun 4th 2018
It is a beautifully designed course. it never gets boring. The best part is that you can learn at your own pace. Thank you all the instructors and Coursera for making the content available.
por MA•Jan 13th 2017
That's was Avery good experience on the course it's really beneficial and very helpful and I want to thank doctors that had taken apart in explaining cancer metastasis thanks very much
Instructores
Kenneth J. Pienta, M.D.
The Donald S. Coffey Professor of UrologyThe James Buchanan Brady Urological Institute
Jelani Zarif
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Sarah Amend
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Haley Axelrod
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Kenneth Valkenburg
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Acerca de Universidad Johns Hopkins
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
Preguntas Frecuentes
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