4.7
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105 calificaciones

Thomas Hartung +1 instructores más

7727 ya inscrito

Ofrecido Por

Evidence-based Toxicology

Universidad Johns Hopkins

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Welcome to the Evidence-based Toxicology (EBT) course. In medicine and healthcare, evidence-based medicine has revolutionized the way that information is evaluated transparently and objectively. Over the past ten years, a movement in North America and Europe has attempted to translate this revolution to the field of toxicology.
The Center for Alternatives to Animal Testing (CAAT) within the department of Environmental Health and Engineering at the Johns Hopkins Bloomberg School of Public Health hosts the first chair for EBT and the secretariat for the EBT Collaboration on both sides of the Atlantic. Based on the Cochrane Collaboration in Evidence-based Medicine, the EBT Collaboration was established at the CAAT to foster the development of a process for quality assurance of new toxicity tests for the assessment of safety in humans and the environment.
Regulatory safety sciences have undergone remarkably little change in the past fifty years. At the same time, our knowledge in the life sciences is doubling about every seven years. Systematic review and related evidence-based approaches are beginning to be adapted by regulatory agencies like the Environment Protection Agency (EPA), the European Food Safety Authority (EFSA), and the US National Toxicology Program. They provide transparent, objective, and consistent tools to identify, select, appraise, and extract evidence across studies. 
This course will showcase these emerging efforts and address opportunities and challenges to the expanded use of these tools within toxicology.

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Nivel principiante

Aprox. 19 horas para completar

Inglés (English)

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Fechas límite flexibles

Restablece las fechas límite en función de tus horarios.

Certificado para compartir

Obtén un certificado al finalizar

100 % en línea

Comienza de inmediato y aprende a tu propio ritmo.

Laboratorios de Coursera

Incluye proyectos de aprendizaje prácticos.

Obtén más información sobre los laboratorios de Coursera

Nivel principiante

Aprox. 19 horas para completar

Inglés (English)

¿Podría tu empresa beneficiarse de la capacitación de los empleados en las habilidades más demandadas?

Prueba Coursera para negocios

Instructores

Calificación del instructor

4,68/5 (29 calificaciones)

Thomas Hartung

Professor

Environmental Health and Engineering

14.718 alumnos

2 cursos

Lena Smirnova

Research Associate

Center for Alternatives to Animal Testing

14.718 alumnos

2 cursos

Ofrecido por

Universidad Johns Hopkins

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Programa - Qué aprenderás en este curso

Semana1

Semana 1

2 horas para completar

Introduction & Shortcomings of Current Approaches

2 horas para completar

9 videos (Total 66 minutos), 3 lecturas, 1 cuestionario

9 videos

Welcome3mIntroduction to the Course14mIntroduction5mShortcoming No. 1: Narrative Reviews7mShortcoming No. 2: Bias in Reviews7mShortcoming No. 3: Evidence Writing4mShortcoming No. 4: External Validity10mShortcoming No. 5: Assessing New Methods5mShortcoming No. 6: Inadequate Reporting7m

3 lecturas

Letter to Learners10mCourse Learning Objectives10mSupporting reading10m

1 ejercicio de práctica

Practice Quiz 130m

Semana2

Semana 2

3 horas para completar

History and Causation

This module explains how evidence-based toxicology originated and describes the driving forces for the initiative. In the second lesson, you will learn how to distinguish between correlation and causation as well as the main problems with drawing conclusions on the basis of correlations. The Bradford Hill criteria are introduced, along with examples for each criterion. You will also learn about mechanistic toxicology and mechanistic validation.

3 horas para completar

11 videos (Total 138 minutos), 2 lecturas, 1 cuestionario

11 videos

Welcome to Module 21mPersonal First Exposures to Evidence-Based Medicine21mThe Start of EBT16mThe First Conference 2007 to the Start of the EBT Collaboration 201114mThe Evidence-Based Toxicology Collaboration (EBTC)13mIntroduction Causation vs. Correlation18mThe Hill Principles of Epidemiology and their Relation to Toxicology16mThe Problem of Causation in Toxicology16mBiomarker Concept in Mechanistic Toxicology4mMechanistic Validation4mThe Future of Causation in Complex Systems9m

2 lecturas

Supporting reading10mSupporting reading10m

1 ejercicio de práctica

Practice Quiz 230m

Semana3

Semana 3

3 horas para completar

Systematic Review and Meta-Analysis

3 horas para completar

8 videos (Total 101 minutos), 2 lecturas, 2 cuestionarios

Semana4

Semana 4

2 horas para completar

Risk of Bias & Application to Test Methods Comparison

This module teaches you about possible biases that can be introduced at different stages of research. Each bias is explained with examples, including solutions for overcoming those biases. The second lesson covers systematic review of the zebrafish embryotoxicity test as a case study conducted by the Evidence-based Toxicology Collaboration (EBTC). You will go through all of the steps of the systematic review again to imprint the knowledge from module 3, but this systematic review will be related to a toxicological method.

2 horas para completar

8 videos (Total 94 minutos), 2 lecturas, 1 cuestionario

8 videos

Welcome to Module 43mIntroduction to Risk of Bias Concept in Critical Appraisal of Studies26mExamples for Risk of Bias Tools 1: Cochrane Collboration4mExamples for Risk of Bias Tools 2: SYRCLE's RoB Tool5mExamples of Risk of Bias Tools 3: National Institute for Environmental Health Sciences (NIEHS) - OHAT12mQuality Assessment in Evidence-Based Toxicology7mEvidence-Based Toxicology (EBT) and Evidence-Based Toxicology Collaboration (EBTC)11mZebrafish Systematic Review22m

2 lecturas

Supporting reading10mSupporting reading10m

1 ejercicio de práctica

Practice Quiz 410m

Semana5

Semana 5

3 horas para completar

Quality Assurance, Good Practices, and Validation

Quality control is a very important aspect of not only modern toxicology but the entirety of life sciences. The first lesson in this module demonstrates the importance of performing quality control on your experiments. The second lesson is connected with the first one because validation of an alternative method requires highly standardized protocols and quality control at each step. This lesson teaches you different aspects of alternatives methods validation, how to perform classical validation, its pitfalls, and strategies to overcome them.

3 horas para completar

10 videos (Total 140 minutos), 2 lecturas, 1 cuestionario

10 videos

Welcome to Module 52mThe Concepts of Quality Assurance (QA) and Good Practice (GP)14mGood Practice22mQuality Assurance12mImportance of GP and QA in EBT5mThe Evolution of Validation of Alternative Methods29mThe Traditional Validation Process26mExample of a Validation Study: Skin Irritation9mDevelopments in the Validation Area6mValidation and Tox-21c/EBT11m

2 lecturas

Supporting reading10mSupporting reading10m

1 ejercicio de práctica

Practice Quiz 530m

Semana6

Semana 6

3 horas para completar

Biometrical Tools & Future Perspectives

Evidence-based toxicology requires some knowledge of bioinformatics. The first lesson in the module teaches you some biostatistical tools you can apply when analyzing predectivity, specificity, and sensitivity of a method. You will also learn how to identify biases in a study with the help of bioinformatics. Evidence-based principles can be applied to every question you might have, even to which pizza to order tonight. You will learn the difference between eminence-based vs. evidence-based approaches. You will learn what is driving the lack of reproducibility and how evidence-based approaches should help to overcome the reproducibility crisis in science, which is explained with examples of experimental design, wrong models, poor quality of the cell cultures, etc.

3 horas para completar

8 videos (Total 98 minutos), 1 lectura, 2 cuestionarios

8 videos

Welcome to Module 64mWhy We Need Biometry/Statistics in Evidence-Based Toxicology9mStatistics and Bioinformatics Applied in Evidence-Based Approaches I11mStatistics and Bioinformatics Applied in Evidence-Based Approaches II18mRisk and Bias and Its Impact on Evidence-Based Approaches12mEvidence-Based Is a More Rigorous Scientific Approach to Anything4mThe Reproducibility Crisis in Science25mWhere Is Evidence-Based Toxicology (EBT) and What Are The Next Steps?11m

1 lectura

Supporting reading10m

2 ejercicios de práctica

Practice quiz 630mFinal exam30m

Semana7

Semana 7

2 horas para completar

Summative Assessment - Systematic Review Assignment

2 horas para completar

1 lectura

Reseñas

4.7

22 reseña

5 stars
76,19 %
4 stars
19,04 %
3 stars
3,80 %
2 stars
0,95 %

Principales reseñas sobre EVIDENCE-BASED TOXICOLOGY

por HH4 de jul. de 2020

Quite informative and exposed me to a whole new horizon in the ever blooming world of toxicology. I would like to thank Dr. Thomas Hartung and his team at John Hopkins for making this possible!

por EE5 de abr. de 2019

Surprisingly very informative and detailed Course. Thanks for the load of information given.

por DJ25 de may. de 2020

Thanks for the opportunity to be part of those who will benefit from their awesome course.

por MM11 de jun. de 2020

The course was very well thought out and very informative

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Preguntas Frecuentes

¿Cuándo podré acceder a las lecciones y tareas?
El acceso a las clases y las asignaciones depende del tipo de inscripción que tengas. Si tomas un curso en modo de oyente, verás la mayoría de los materiales del curso en forma gratuita. Para acceder a asignaciones calificadas y obtener un certificado, deberás comprar la experiencia de Certificado, ya sea durante o después de participar como oyente. Si no ves la opción de oyente:
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Es posible que el curso ofrezca la opción 'Curso completo, sin certificado'. Esta opción te permite ver todos los materiales del curso, enviar las evaluaciones requeridas y obtener una calificación final. También significa que no podrás comprar una experiencia de Certificado.
¿Qué recibiré si compro el Certificado?
Cuando compras un Certificado, obtienes acceso a todos los materiales del curso, incluidas las tareas calificadas. Una vez que completes el curso, se añadirá tu Certificado electrónico a la página Logros. Desde allí, puedes imprimir tu Certificado o añadirlo a tu perfil de LinkedIn. Si solo quieres leer y visualizar el contenido del curso, puedes participar del curso como oyente sin costo.
¿Hay ayuda económica disponible?
Sí. En ciertos programas de aprendizaje, puedes postularte para recibir ayuda económica o una beca en caso de no poder costear los gastos de la tarifa de inscripción. Si hay ayuda económica o becas disponibles para tu selección de programa de aprendizaje, verás un enlace para postularte en la página de descripción.

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Evidence-based Toxicology

Evidence-based Toxicology

Acerca de este Curso