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Learner Reviews & Feedback for Experimental Methods in Systems Biology by Icahn School of Medicine at Mount Sinai

4.5
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308 ratings

About the Course

Learn about the technologies underlying experimentation used in systems biology, with particular focus on RNA sequencing, mass spec-based proteomics, flow/mass cytometry and live-cell imaging. A key driver of the systems biology field is the technology allowing us to delve deeper and wider into how cells respond to experimental perturbations. This in turns allows us to build more detailed quantitative models of cellular function, which can give important insight into applications ranging from biotechnology to human disease. This course gives a broad overview of a variety of current experimental techniques used in modern systems biology, with focus on obtaining the quantitative data needed for computational modeling purposes in downstream analyses. We dive deeply into four technologies in particular, mRNA sequencing, mass spectrometry-based proteomics, flow/mass cytometry, and live-cell imaging. These techniques are often used in systems biology and range from genome-wide coverage to single molecule coverage, millions of cells to single cells, and single time points to frequently sampled time courses. We present not only the theoretical background upon which these technologies work, but also enter real wet lab environments to provide instruction on how these techniques are performed in practice, and how resultant data are analyzed for quality and content....

Top reviews

AH

Nov 29, 2020

Amazing course, only the final exam was rather an excercise in finding out out where the answers differ than trying to really understand what should be the ringht answer. I learnt a lot, thank you!

MD

Jun 20, 2021

The lab videos are great, thanks for teaching us. Not all university can afford those machines. If you have latest methods or anything please introduce more courses.

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51 - 54 of 54 Reviews for Experimental Methods in Systems Biology

By Jorge A G M

•

Jan 9, 2024

Once again, I have mixed feelings about this course. On the bright side, it was very comprehensive and cover a wide collection of experimental methods, which to me, as a non biologist getting into systems biology, has always been one of the most confusing aspects of the field. I also appreciate a lot the idea of lab recordings, so you have a better idea of how everything looks in real life; it makes it feel more real. On the other side, lectures are in general very long and tedious. Methods generally consist of a series of several and non trivial steps, for which usually one or two slides are shown. I understand this course is more than 10 years old and video or animations were not that available, but either or even a pointer, are very necessary. To anyone taking the course, I would recommend to use the syllabus as a guide and look for online videos or animations on YouTube, there are plenty and very, very helpful to understand these processes

By Pooja P

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Aug 15, 2016

The course was very interesting. It touched upon all currently employed techniques in good detail. The lab-based videos were the most interesting. However, the lectures were too long. It would be a brilliant course if the lectures were cut short and made to the point.

By Rohaina T

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Sep 29, 2016

The questions based on the lectures are quite different and confusing

By Alison P

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Apr 16, 2018

quiz 5 from week 6 does not work.