Acerca de este Curso
4.8
143 calificaciones
30 revisiones
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100% online

Comienza de inmediato y aprende a tu propio ritmo.
Fechas límite flexibles

Fechas límite flexibles

Restablece las fechas límite en función de tus horarios.
Hours to complete

Aprox. 14 horas para completar

Sugerido: 2-4 hours/week...
Available languages

Inglés (English)

Subtítulos: Inglés (English)...
100% online

100% online

Comienza de inmediato y aprende a tu propio ritmo.
Fechas límite flexibles

Fechas límite flexibles

Restablece las fechas límite en función de tus horarios.
Hours to complete

Aprox. 14 horas para completar

Sugerido: 2-4 hours/week...
Available languages

Inglés (English)

Subtítulos: Inglés (English)...

Programa - Qué aprenderás en este curso

Semana
1
Hours to complete
3 horas para completar

UNIT 1: INTRODUCTION TO PERSONALIZED MEDICINE

The first module of this course will focus on introducing the concept of personalized medicine. We will very briefly review fundamentals of genetics as these apply to personalized medicine (DNA structure; RNA; protein structures; function of DNA; coding; DNA variations; types of genetic variants), as well as review statistical concepts and skills important to clinical data analysis (odds ratios, relative risk, P values, multiple testing, sensitivity, specificity, ROCs). In Module 2 we will explore drug actions and reactions as we look closely at the general mechanisms underlying variability in drug responses, drug metabolism and transport, and genetic variability in drug-handling molecules....
Reading
11 videos (Total: 120 min), 1 reading, 1 quiz
Video11 videos
Introduction to Personalized Medicine11m
Genetics Definitions, Part I14m
Genetics Definitions, Part II & Types of Genetic Variants15m
Data Analysis, Part I: What is a Good Study?12m
Data Analysis, Part II: What is a Good Test?7m
Introduction to Drug Therapy and General Mechanisms Underlying Variability in Drug Responses13m
Variability in Drug Therapy15m
Drug Metabolism & Transport13m
Genetic Variability in Drug-Handling Molecules10m
**Inside VUMC: The Promise of Personalized Medicine1m
Reading1 lecturas
About this course10m
Quiz1 ejercicios de práctica
Introduction to Personalized Medicine12m
Semana
2
Hours to complete
2 horas para completar

UNIT 2: STUDYING GENETIC VARIATION

Module 3 focuses on how we study genetic variation. We'll start by looking at families and populations. Topics that will be introduced include family history and inheritance patterns, ancestry, and linkage. Then in Module 4 we shift our focus to studying the contemporary techniques and technologies used to study genetic variation, including genome-wide association and sequencing....
Reading
7 videos (Total: 104 min), 1 quiz
Video7 videos
Ancestry: Genetic Variation Across Generations and Geography17m
Finding Disease-Associated Genes: Linkage10m
**Inside VUMC: From Phenotype to Genotype and Back: Studying Heart Disease in Families1m
Genome-Wide Association25m
Sequencing28m
**Inside VUMC: History of Sequencing Technologies1m
Quiz1 ejercicios de práctica
Studying Genetic Variation12m
Semana
3
Hours to complete
3 horas para completar

UNIT 3: CASE STUDIES IN PERSONALIZED MEDICINE, PART 1

In Module 5 we will begin to discuss specific cases as these apply to personalized medicine. We will first look very closely at a case of familial hypercholesterolemia as we investigate how we use genomic medicine to move from a rare disease to a common medication, using genomics to find new drug targets, and a discussion of the side effects of statin therapy. In Module 6 we will look at a collection of "high risk pharmacogenetics"cases that illustrate adverse reactions due to drug metabolism and variable drug responses....
Reading
13 videos (Total: 174 min), 1 quiz
Video13 videos
Using Genomics to Find New Drug Targets: Familial Hypercholesterolemia16m
Muscle Pains During Statin Therapy (Myopathy)13m
HLA-Mediated Immune Reactions (Skin Rash)9m
Long QT Syndromes, Part 115m
Long QT Syndromes, Part 218m
**Inside VUMC: Studying Cardiac Arrhythmias in Cells4m
A Second Heart Attack a Month After a First15m
Headache During Venlafaxine (Antidepressant)16m
Respiratory Arrest After Tonsillectomy10m
A Bleeding Complication 5 Days After Starting Warfarin21m
**Inside VUMC: Genotyping1m
Drug Metabolism and Variable Drug Responses – Four More Examples17m
Quiz1 ejercicios de práctica
Case Studies, Part I16m
Semana
4
Hours to complete
2 horas para completar

UNIT 4: CASE STUDIES IN PERSONALIZED MEDICINE, PART 2

Module 7 continues our focus on case studies with a look at some cases that illustrate how personalized medicine informs treatment decisions related to specific diseases/conditions. These include cystic fibrosis, Marfan syndrome, heart failure, neuropsychiatric diseases, and diabetes. Three cases/lessons focus specifically on how genomic medicine informs testing for and treatment of cancer. ...
Reading
9 videos (Total: 119 min), 1 quiz
Video9 videos
Marfan Syndrome11m
A Case of Idiopathic Heart Failure16m
Personalizing Care in Neuropsychiatric Disease18m
Personalizing Care in Diabetes21m
Genomics to Subtype Cancer11m
A Family Member With Breast Cancer14m
A Family Member With Colon Cancer11m
**Inside VUMC: Organizing Infrastructure to Support Genetic Testing Decisions1m
Quiz1 ejercicios de práctica
Case Studies, Part II10m
4.8
30 revisionesChevron Right

Principales revisiones

por MTApr 24th 2017

I learned more about pharmacogenomics and its application, which is crucial for my career development as a young graduate in biology who is pursuing health sciences.

por CZNov 13th 2016

Thank you! I think I'm going to review/re-take this course at least one more time as the lectures are really interesting and insightful.

Instructores

Avatar

Dan Roden, M.D.

Professor of Medicine and Pharmacology
Assistant Vice Chancellor for Personalized Medicine

Acerca de Vanderbilt University

Vanderbilt University, located in Nashville, Tenn., is a private research university and medical center offering a full-range of undergraduate, graduate and professional degrees....

Preguntas Frecuentes

  • Una vez que te inscribes para obtener un Certificado, tendrás acceso a todos los videos, cuestionarios y tareas de programación (si corresponde). Las tareas calificadas por compañeros solo pueden enviarse y revisarse una vez que haya comenzado tu sesión. Si eliges explorar el curso sin comprarlo, es posible que no puedas acceder a determinadas tareas.

  • Cuando compras un Certificado, obtienes acceso a todos los materiales del curso, incluidas las tareas calificadas. Una vez que completes el curso, se añadirá tu Certificado electrónico a la página Logros. Desde allí, puedes imprimir tu Certificado o añadirlo a tu perfil de LinkedIn. Si solo quieres leer y visualizar el contenido del curso, puedes participar del curso como oyente sin costo.

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