This course is geared towards starting undergraduate students. A solid background in biology will be helpful but not absolutely essential. The material will be of interest to those who are pursuing a career in any of the life sciences as well as anyone who has run up against their biological clock.
Circadian clocks: how rhythms structure life
ofrecido por
Ludwig-Maximilians-Universität München (LMU)
Programa - Qué aprenderás en este curso
Semana
12 horas para completar
WEEK 1
Introduction to 'chronobiology'. What sorts of rhythms are observed in nature? Most of the lecture will be spent on describing daily or circadian rhythms in organisms from bacteria to man.
9 videos (Total 62 minutos), 1 reading, 2 quizzes
9 videos
1.1 The Family of Biological Rhythms 7m
1.2 The Circa-Rhythms5m
1.3 Spatial and Temporal Niches3m
1.4 The Case of Gonyaulax polyedra 6m
1.5 Introduction to the Second Half of Lecture 1 50s
1.6 Circadian Rhythms in Mammals 7m
1.7 Circadian Clocks in Flies, Plants and Fungi12m
1.8 Wrap up for Lecture 118m
1 lectura
Literature suggestion10m
2 ejercicios de práctica
Lecture 1, Introduction, first half.10m
Lecture 1, Introduction, second half.10m
Semana
21 hora para completar
WEEK 2
Circadian rhythms synchronise to the 24-hour environment. Organisms use specialised photoreceptors to do this and they display characteristic properties in this process. We experience this active synchronisation process for example when we suffer from jet lag!
5 videos (Total 46 minutos), 3 readings, 1 quiz
5 videos
2.1 Pittendrigh´s generalisations 1-9 17m
2.2 Pittendrigh´s generalisations 10 and 11 7m
2.3 Pittendrigh´s generalisations 12-16 and entrainment11m
2.4 Wrap-up for Lecture 28m
3 lecturas
Literature suggestion10m
Translation of de Mairan's botanical observation5m
Obituary Jürgen Aschoff10m
1 ejercicio de práctica
Formalisms12m
Semana
31 hora para completar
WEEK 3
We will discuss the elaborate molecular mechanisms that allow circadian clocks to produce their daily rhythms and to synchronise them to its environment. We will compare these mechanisms in a wide range of organisms.
8 videos (Total 62 minutos), 1 reading, 1 quiz
8 videos
3.1 The first clock gene8m
3.2 The negative feedback hypothesis 15m
3.3 More clock genes -many more! 5m
3.4 Post transcriptional mechanisms and the clock 11m
3.5 Indications of a non-transcriptional clock 6m
3.6 Zeitgebers and the molecular clockwork9m
3.7 Wrap-up to Lecture 34m
1 lectura
Literature suggestion10m
1 ejercicio de práctica
Lecture 3 Molecular mechanisms12m
Semana
41 hora para completar
WEEK 4
Circadian clocks serve to orchestrate physiology and metabolism in a coordinated way over the course of the day. Therefore, practically all processes in an organism are regulated outputs of the clock. We'll discuss examples of these processes and ideas about how this circadian regulation works.
8 videos (Total 60 minutos), 1 reading, 1 quiz
8 videos
4.1 Clock control: which processes in humans and how to measure them? 10m
4.2 Schwänzeltanz 5m
4.3 The SCN regulates the timing of physiology and behaviour 3m
4.4 Clock controlled genes (ccg´s) 14m
4.5 Clock regulation of behaviour: genetic mechanisms 5m
4.6 Clock regulation of other major regulatory systems 4m
4.7 Wrap-Up to Lecture 414m
1 lectura
Literature suggestion10m
1 ejercicio de práctica
Lecture 4: Clock control10m
Instructores
Martha Merrow
ProfessorMedical Psychology
Till Roenneberg
ProfessorMedical Psychology
Acerca de Ludwig-Maximilians-Universität München (LMU)
As one of Europe's leading research universities, LMU Munich is committed to the highest international standards of excellence in research and teaching. Building on its 500-year-tradition of scholarship, LMU covers a broad spectrum of disciplines, ranging from the humanities and cultural studies through law, economics and social studies to medicine and the sciences.
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