SEMANA 1

WEEK 1

Introduction to 'chronobiology'. What sorts of rhythms are observed in nature? Most of the lecture will be spent on describing daily or circadian rhythms in organisms from bacteria to man.

9 videos, 1 lectura

Vídeo: 1.1 The Family of Biological Rhythms
Vídeo: 1.2 The Circa-Rhythms
Vídeo: 1.3 Spatial and Temporal Niches
Vídeo: 1.4 The Case of Gonyaulax polyedra
Vídeo: 1.5 Introduction to the Second Half of Lecture 1
Vídeo: 1.6 Circadian Rhythms in Mammals
Vídeo: 1.7 Circadian Clocks in Flies, Plants and Fungi
Vídeo: 1.8 Wrap up for Lecture 1
Reading: Literature suggestion

Calificado: Lecture 1, Introduction, first half.

Calificado: Lecture 1, Introduction, second half.

SEMANA 2

WEEK 2

Circadian rhythms synchronise to the 24-hour environment. Organisms use specialised photoreceptors to do this and they display characteristic properties in this process. We experience this active synchronisation process for example when we suffer from jet lag!

5 videos, 3 lecturas

Vídeo: 2.1 Pittendrigh´s generalisations 1-9
Vídeo: 2.2 Pittendrigh´s generalisations 10 and 11
Vídeo: 2.3 Pittendrigh´s generalisations 12-16 and entrainment
Vídeo: 2.4 Wrap-up for Lecture 2
Reading: Literature suggestion
Reading: Translation of de Mairan's botanical observation
Reading: Obituary Jürgen Aschoff

Calificado: Formalisms

SEMANA 3

WEEK 3

We will discuss the elaborate molecular mechanisms that allow circadian clocks to produce their daily rhythms and to synchronise them to its environment. We will compare these mechanisms in a wide range of organisms.

8 videos, 1 lectura

Vídeo: 3.1 The first clock gene
Vídeo: 3.2 The negative feedback hypothesis
Vídeo: 3.3 More clock genes -many more!
Vídeo: 3.4 Post transcriptional mechanisms and the clock
Vídeo: 3.5 Indications of a non-transcriptional clock
Vídeo: 3.6 Zeitgebers and the molecular clockwork
Vídeo: 3.7 Wrap-up to Lecture 3
Reading: Literature suggestion

Calificado: Lecture 3 Molecular mechanisms

SEMANA 4

WEEK 4

Circadian clocks serve to orchestrate physiology and metabolism in a coordinated way over the course of the day. Therefore, practically all processes in an organism are regulated outputs of the clock. We'll discuss examples of these processes and ideas about how this circadian regulation works.

8 videos, 1 lectura

Vídeo: 4.1 Clock control: which processes in humans and how to measure them?
Vídeo: 4.2 Schwänzeltanz
Vídeo: 4.3 The SCN regulates the timing of physiology and behaviour
Vídeo: 4.4 Clock controlled genes (ccg´s)
Vídeo: 4.5 Clock regulation of behaviour: genetic mechanisms
Vídeo: 4.6 Clock regulation of other major regulatory systems
Vídeo: 4.7 Wrap-Up to Lecture 4
Reading: Literature suggestion

Calificado: Lecture 4: Clock control

SEMANA 5

WEEK 5

With the appreciation of the clock’s global control, we proceed to discussing how much this temporal programme controls our lives from birth to death and how much we mistreat the circadian clock in modern life.

6 videos, 1 lectura

Vídeo: 5.1 Chronotypes
Vídeo: 5.2 What makes up Chronotypes?
Vídeo: 5.3 Linking chronotype and light entrainment
Vídeo: 5.4 How modern life styles affect sleep
Vídeo: 5.5 Wrap-up to Lecture 5
Reading: The link to the MCTQ

Calificado: Human

SEMANA 6

WEEK 6

Finally, we will look at the clock’s relationship to pathology. What are the consequences of living against the clock, what happens if the clock ‘breaks’, and how can we use our knowledge about the circadian system in medical diagnosis and therapy.

11 videos, 1 cuestionario de práctica

Vídeo: 6.1 What is normal and what not and why?
Vídeo: 6.2 The consequences of living against the clock
Vídeo: 6.3 Circadian changes and Pathologies - comorbidities or causal factors
Vídeo: 6.4 Introduction to the Second Half of Lecture 6
Vídeo: 6.5 Clock genes that can really mess up the timing of sleep
Vídeo: 6.6 The clock gene mutant mice are sick
Vídeo: 6.7 Chronopharmacology and chronochemotherapy
Vídeo: 6.8 The circadian clock is a fitness characteristic
Vídeo: 6.9 Wrap-up to Lecture 6
Vídeo: 6.10 Farewell from your CircaClock Team
Teste para praticar: Final Exam "Circaclock"
Avaliação entre colegas: Peer-Reviewed Assignment

Calificado: Pathology

Calificado: Lecture 6. Clock and pathologies

Idioma	Inglés (English)
Cómo aprobar	Aprueba todas las tareas calificadas para completar el curso.

Circadian clocks: how rhythms structure life

Circadian clocks: how rhythms structure life