This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.
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Toxicology 21: Scientific Applications
Universidad Johns Hopkins
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Fechas límite flexibles
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Nivel intermedio
Aprox. 26 horas para completar
Sugerido: 6 weeks of study, 3-6 hours per week
Inglés (English)
Subtítulos: Inglés (English)
Programa - Qué aprenderás en este curso
75 horas para completar
Module 1
This model will give you a broad introduction to the Toxicology 21st century (Tox21c) field and familiarize you with the main document, which summarize the main ideas and principles of Tox21c.
75 horas para completar
10 videos (Total 121 minutos), 3 lecturas, 1 cuestionario
10 videos
Course Introduction16m
Introduction49s
Center for Alternatives to Animal Testing4m
Toxicology of the Fifteenth to Twentieth Centuries15m
Toxicology for the Twenty-First Century15m
Historical Perspective17m
The First Report: Toxicity Testing for Assessment of Environmental Agents11m
The Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components22m
The Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation13m
3 lecturas
useful links20m
supporting reading material10m
Supporting reading material10m
1 ejercicio de práctica
Module 1 Quizs
5 horas para completar
Module 2
This module will discuss how ToxCast and Tox21 technologies can be used in practice. The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of . In the second lesson of this module, the development of in silico models for toxicity testing will be discussed.
5 horas para completar
10 videos (Total 119 minutos), 4 lecturas, 2 cuestionarios
10 videos
Adverse Outcome Pathways (AOPs)10m
Exposure-Based Chemical Prioritization13m
ER Bioactivity Model16m
US EPA Endocrine Disruptor Screening Program (EDSP)17m
Modeling of Hazard and Organ Manifestation11m
Building a Signature for Vascular Disruption10m
Testing the Vascular Disruption Signature8m
Virtual Tissue Model: Vascular Development12m
Functional Vascular Development Assays16m
4 lecturas
Supporting Reading Material10m
Useful links10m
Supporting Reading Material10m
Useful links10m
1 ejercicio de práctica
Module 2 Quiz8m
3 horas para completar
Module 3
This module will familiarize you with the Human Toxome Project run by Johns Hopkins University in collaboration with several university, industry, and research agencies. Omics technologies, their advantages and disadvantages, as well as concepts of Adverse Outcome Pathways (AOP) and Pathways of Toxicity (PoT) will be discussed.
3 horas para completar
11 videos (Total 126 minutos), 2 lecturas, 1 cuestionario
11 videos
Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology16m
The Concept of the Human Toxome Project21m
Concept and Tool Devlopment11m
Progress7m
Conclusions and Prospectives8m
Introduction - What Is a Pathway of Toxicity, and Why Do We Need Them?6m
Omics Technologies and High-Throughput Data11m
Interpreting Omics Data11m
PoT Examples and Conclusions15m
Pathways of Toxicity and Adverse Outcome Pathways (AOPs)13m
2 lecturas
Supporting reading materials10m
Supporting reading material10m
1 ejercicio de práctica
Module 3 Quiz8m
4 horas para completar
Module 4
The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation. The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches.
4 horas para completar
15 videos (Total 148 minutos), 3 lecturas, 2 cuestionarios
15 videos
The Concept of Toxicological (Biological) Pathways, e.g., “Adverse Outcome Pathways,” Is the Basis of Predictive Toxicology5m
Introduction to the OECD AOP Framework10m
Building, Evaluating, and Using AOPs in Safety Decisions6m
Online Tools Available to Everyone, Including an Online AOP Course4m
Welcome to Module 42m
Introduction to Read-Across18m
Good Read-Across Practice21m
Supporting Read-Across with Biological Data12m
Creating a Database of Toxicity12m
Creating an Automated Tool for Read-Across9m
Paradigm Shift in Toxicology7m
2D In Vitro Cell Culture8m
3D In Vitro Cell Cultures8m
Organ-on-a-Chip11m
3 lecturas
Supporting reading material10m
Supporting reading material10m
Useful links10m
2 ejercicios de práctica
Module 4 Quiz8m
Mid-term exam44m
1 hora para completar
Module 5
This module will teach you the role of miRNA and epigenetics in toxicology and environmental health.
1 hora para completar
6 videos (Total 41 minutos), 1 lectura, 1 cuestionario
6 videos
MicroRNA and Epigenetics4m
Epigenetics and Environment6m
MicroRNA: Biogenesis and Functions11m
Role of MicroRNA in Development6m
MicroRNA in Toxicology9m
1 lectura
Supporting reading material10m
1 ejercicio de práctica
Module 5 Quiz8m
Principales revisiones sobre Toxicology 21: Scientific Applications
Very nicely designed course. The instructors offer an excellent and easy to understand overview of a range of promising Tox21 tools and approaches using good examples and illustrations.
A very well-taught course with lots of useful information. I highly recommend it.
Acerca de Universidad Johns Hopkins
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
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