In previous courses in the Specialization, we have discussed how to sequence and compare genomes. This course will cover advanced topics in finding mutations lurking within DNA and proteins.
Este curso forma parte de Programa Especializado - Bioinformática
Finding Mutations in DNA and Proteins (Bioinformatics VI)
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Nivel principiante
Aprox. 21 horas para completar
Inglés (English)
Subtítulos: Inglés (English)
Programa - Qué aprenderás en este curso
4 horas para completar
Week 1: Introduction to Read Mapping
<p>Welcome to our class! We are glad that you decided to join us.</p><p>In this class, we will consider the following two central biological questions (the computational approaches needed to solve them are shown in parentheses):</p><ol><li>How Do We Locate Disease-Causing Mutations? (<em>Combinatorial Pattern Matching</em>)</li><li>Why Have Biologists Still Not Developed an HIV Vaccine? (<em>Hidden Markov Models</em>)</li></ol><p>As in previous courses, each of these two chapters is accompanied by a Bioinformatics Cartoon created by talented artist Randall Christopher and serving as a chapter header in the Specialization's bestselling <a href="http://bioinformaticsalgorithms.com" target="_blank">print companion</a>. You can find the first chapter's cartoon at the bottom of this message. </p><p><img src="https://stepic.org/media/attachments/lessons/292/chapter7_cropped.jpg" title="Image: https://stepic.org/media/attachments/lessons/292/chapter7_cropped.jpg" width="528"></p>
4 horas para completar
4 videos (Total 33 minutos), 2 lecturas, 3 cuestionarios
4 videos
Why Do We Map Reads? 7m
Using the Trie 10m
From a Trie to a Suffix Tree 11m
2 lecturas
Course Details10m
Week 1 FAQs (Optional)
1 ejercicio de práctica
How Do We Find Disease-Causing Mutations? (Week 1)15m
4 horas para completar
Week 2: The Burrows-Wheeler Transform
<p>Welcome to week 2 of the class!</p>
4 horas para completar
3 videos (Total 21 minutos), 1 lectura, 2 cuestionarios
3 videos
Inverting Burrows-Wheeler 13m
Using Burrows-Wheeler for Pattern Matching 2m
1 lectura
Week 2 FAQs (Optional)
4 horas para completar
Week 3: Speeding Up Burrows-Wheeler Read Mapping
<p>Welcome to week 3 of class!</p>
4 horas para completar
4 videos (Total 22 minutos), 1 lectura, 3 cuestionarios
4 videos
Setting Up Checkpoints 8m
Inexact Matching 6m
Further Applications of Read Mapping 2m
1 lectura
Week 3 FAQs (Optional)
1 ejercicio de práctica
How Do We Find Disease-Causing Mutations? (Weeks 2-3)20m
4 horas para completar
Week 4: Introduction to Hidden Markov Models
<p>Welcome to week 4 of class!</p>
4 horas para completar
5 videos (Total 42 minutos)
5 videos
Gambling with Yakuza 12m
From a Crooked Casino to a Hidden Markov Model 9m
The Decoding Problem 5m
The Viterbi Algorithm 7m
Revisiones
4.6
Principales revisiones sobre FINDING MUTATIONS IN DNA AND PROTEINS (BIOINFORMATICS VI)
por TKJun 28, 2016
One of the best specialization on Coursera. Highly recommended for anyone who wants to apply his/her programming skills to fascinating real-world problems.
por DCSep 15, 2018
Really enjoyed this course. It was great to get to build on work from previous courses.
por ZXJul 20, 2019
In depth and comprehensive coverage of the topics in genetic data analysis.
Acerca de Universidad de California en San Diego
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Acerca de Programa especializado Bioinformática
Join Us in a Top 50 MOOC of All Time!
How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth?
When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science.
Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional!
Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video.
You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website.
Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!
Preguntas Frecuentes
¿Cuándo podré acceder a las lecciones y tareas?
Una vez que te inscribes para obtener un Certificado, tendrás acceso a todos los videos, cuestionarios y tareas de programación (si corresponde). Las tareas calificadas por compañeros solo pueden enviarse y revisarse una vez que haya comenzado tu sesión. Si eliges explorar el curso sin comprarlo, es posible que no puedas acceder a determinadas tareas.
¿Qué recibiré si me suscribo a este Programa especializado?
Cuando te inscribes en un curso, obtienes acceso a todos los cursos que forman parte del Programa especializado y te darán un Certificado cuando completes el trabajo. Se añadirá tu Certificado electrónico a la página Logros. Desde allí, puedes imprimir tu Certificado o añadirlo a tu perfil de LinkedIn. Si solo quieres leer y visualizar el contenido del curso, puedes auditar el curso sin costo.
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