Acerca de este Curso
4.8
154 calificaciones
34 revisiones
You may have heard a lot about genome sequencing and its potential to usher in an era of personalized medicine, but what does it mean to sequence a genome? Biologists still cannot read the nucleotides of an entire genome as you would read a book from beginning to end. However, they can read short pieces of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces. We will further learn about brute force algorithms and apply them to sequencing mini-proteins called antibiotics. In the first half of the course, we will see that biologists cannot read the 3 billion nucleotides of a human genome as you would read a book from beginning to end. However, they can read shorter fragments of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces in what amounts to the largest jigsaw puzzle ever put together. In the second half of the course, we will discuss antibiotics, a topic of great relevance as antimicrobial-resistant bacteria like MRSA are on the rise. You know antibiotics as drugs, but on the molecular level they are short mini-proteins that have been engineered by bacteria to kill their enemies. Determining the sequence of amino acids making up one of these antibiotics is an important research problem, and one that is similar to that of sequencing a genome by assembling tiny fragments of DNA. We will see how brute force algorithms that try every possible solution are able to identify naturally occurring antibiotics so that they can be synthesized in a lab. Finally, you will learn how to apply popular bioinformatics software tools to sequence the genome of a deadly Staphylococcus bacterium that has acquired antibiotics resistance....
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Beginner Level

Nivel principiante

Clock

Approx. 15 hours to complete

Sugerido: 3 hours/week...
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English

Subtítulos: English, Chinese (Simplified)...

Habilidades que obtendrás

AlgorithmsPython ProgrammingWhole Genome SequencingDynamic Programming
Globe

Cursos 100 % en línea

Comienza de inmediato y aprende a tu propio ritmo.
Calendar

Fechas límite flexibles

Restablece las fechas límite en función de tus horarios.
Beginner Level

Nivel principiante

Clock

Approx. 15 hours to complete

Sugerido: 3 hours/week...
Comment Dots

English

Subtítulos: English, Chinese (Simplified)...

Programa - Qué aprenderás en este curso

Week
1
Clock
4 horas para completar

Week 1: Introduction to Genome Sequencing

<p>Welcome to class!</p><p>This course will focus on two questions at the forefront of modern computational biology, along with the algorithmic approaches we will use to solve them in parentheses:</p><ol><li>Weeks 1-2: How Do We Assemble Genomes? (<i>Graph Algorithms</i>)</li><li>How Do We Sequence Antibiotics? (<i>Brute Force Algorithms</i>)</li></ol><p>Each of the two chapters of content in the class is accompanied by a Bioinformatics Cartoon created by talented San Diego artist Randall Christopher and serving as a chapter header in the Specialization's bestselling <a href="http://bioinformaticsalgorithms.com" target="_blank">print companion</a>. You can find the first chapter's cartoon at the bottom of this message. What does a time machine trip to 1735, a stack of newspapers, a jigsaw puzzle, and a giant ant invading a riverside city have to do with putting together a genome? Start learning today to find out!</p><p><img src="https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter4_final_lr.jpg" title="Image: https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter4_final_lr.jpg" width="528"></p>...
Reading
8 videos (Total: 36 min), 2 readings, 3 quizzes
Video8 videos
FIELD TRIP!4m
What Is Genome Sequencing?6m
Exploding Newspapers4m
The String Reconstruction Problem3m
String Reconstruction as a Hamiltonian Path Problem3m
String Reconstruction as an Eulerian Path Problem5m
Similar Problems with Different Fates 3m
Reading2 lecturas
Course Details10m
Week 1 FAQs (Optional)m
Quiz1 ejercicio de práctica
Week 1 Quiz15m
Week
2
Clock
3 horas para completar

Week 2: Applying Euler's Theorem to Assemble Genomes

<p>Welcome to Week 2 of class!</p> <p>This week in class, we will see how a 300 year-old mathematical theorem will help us assemble a genome from millions of tiny pieces of DNA.</p>...
Reading
5 videos (Total: 28 min), 1 reading, 3 quizzes
Video5 videos
Euler's Theorem 6m
Assembling Read-Pairs 8m
De Bruijn Graphs Face Harsh Realities of Assembly 4m
Returning to Konigsberg 1m
Reading1 lectura
Week 2 FAQs (Optional)m
Quiz1 ejercicio de práctica
Week 2 Quiz15m
Week
3
Clock
4 horas para completar

Week 3: Sequencing Antibiotics

<p>Welcome to Week 3 of class!</p> <p>This week, we begin a new chapter, titled "How Do We Sequence Antibiotics?" &nbsp;In this chapter, we will learn&nbsp;how to determine the amino acid sequences making up antibiotics using brute force algorithms.</p> <p>Below is this week's Bioinformatics Cartoon.</p> <p><img src="https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter2_final.jpg" title="Image: https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter2_final.jpg" width="528"></p>...
Reading
5 videos (Total: 27 min), 1 reading, 3 quizzes
Video5 videos
How Do Bacteria Make Antibiotics? 8m
Sequencing Antibiotics by Shattering Them into Pieces 4m
A Brute Force Algorithm for Cyclopeptide Sequencing 3m
Cyclopeptide Sequencing with Branch and Bound 6m
Reading1 lectura
Week 3 FAQs (Optional)m
Quiz1 ejercicio de práctica
Week 3 Quiz15m
Week
4
Clock
3 horas para completar

Week 4: From Ideal to Real Spectra for Antibiotics Sequencing

<p>Welcome to Week 4 of class!</p> <p>Last week, we discussed how to sequence an antibiotic peptide from an ideal spectrum. This week, we will see how to develop more sophisticated algorithms for antibiotic peptide sequencing that are able to handle spectra with many false and missing masses.</p>...
Reading
4 videos (Total: 18 min), 1 reading, 3 quizzes
Video4 videos
From 20 to More than 100 Amino Acids 2m
The Spectral Convolution Saves the Day 6m
The Truth About Spectra 2m
Reading1 lectura
Week 4 FAQs (Optional)m
Quiz1 ejercicio de práctica
Week 4 Quiz15m
4.8
Direction Signs

50%

comenzó una nueva carrera después de completar estos cursos
Briefcase

83%

consiguió un beneficio tangible en su carrera profesional gracias a este curso

Principales revisiones

por SVJan 10th 2017

Great course to explore a bit of Bioinformatics for those with no background in Bioinformatics. I love the way the content has been provided, its interactivity increases the interest in the course.

por MPDec 8th 2017

I like the real-world tasks, especially the assembly on the final exam. Some of the programming tasks, such as the antibiotic noisy spectrum assembly, are challenging (which is good).

Instructores

Pavel Pevzner

Professor
Department of Computer Science and Engineering

Phillip Compeau

Visiting Researcher
Department of Computer Science & Engineering

Acerca de University of California San Diego

UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory....

Acerca del programa especializado Bioinformatics

Join Us in a Top 50 MOOC of All Time! How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth? When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science. Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional! Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video. You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website. Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!...
Bioinformatics

Preguntas Frecuentes

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you enroll in the course, you get access to all of the courses in the Specialization, and you earn a certificate when you complete the work. Your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

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